Preoperative localization of hyperfunctioning parathyroid glands with 4D-CT

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Anke Katrin LundstroemPeter Sand Myschetzky

Abstract

Primary hyperparathyroidism (pHPT) is almost exclusively the result of a solitary parathyroid adenoma. In most cases, the affected gland can be surgically removed, but precise preoperative imaging is essential for adenoma localization prior to surgical intervention. In this study, we evaluated the diagnostic value of four-dimensional computed tomography (4D-CT) as a preoperative imaging tool in relation to the localization of pathologic parathyroid glands in patients with pHPT and negative sestamibi scans. This study included 43 consecutive patients with pHPT referred for parathyroidectomy at the Department of Head and Neck Surgery of Copenhagen University Hospital Rigshospitalet in 2011 and 2012. All patients had a 4D-CT performed prior to parathyroidectomy. CT localization of the suspected adenoma was correlated to the actual surgical findings and subsequent histological diagnosis was also available as references for the accuracy of this imaging tool. Hyperfunctioning parathyroid glands were found in 40 patients. 4D-CT identified 32 solitary hyperfunctioning parathyroid glands located on the correct side of the neck (PPV 76 %) and 21 located within the correct quadrant (PPV 49 %). Unilateral resection was performed in 72 % of...Continue Reading

References

Nov 1, 1991·World Journal of Surgery·J A van Heerden, C S Grant
Mar 1, 1986·Annals of Surgery·C A PatowM F Brennan
Jun 26, 1998·Langenbeck's Archives of Surgery·C MarietteC Proye
Mar 5, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·James M RudaBrendan C Stack
Sep 1, 2009·Journal of the American College of Surgeons·Andrew B GreeneMira Milas
Dec 24, 2010·AJR. American Journal of Roentgenology·Michael D BelandJack M Monchik
Dec 25, 2010·Annals of Surgical Oncology·Lee F StarkerTobias Carling
Nov 5, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Emily Z StuckenWilliam I Kuhel
Dec 3, 2011·AJNR. American Journal of Neuroradiology·J L ChazenC D Phillips
Apr 25, 2012·Annals of Surgical Oncology·Carrie C Lubitz, Herbert Chen
Aug 10, 2012·Advances in Surgery·John W Kunstman, Robert Udelsman

❮ Previous
Next ❯

Citations

Apr 16, 2018·Journal of Medical Imaging and Radiation Oncology·Phelipe Cunha-BezerraFrancisco Bandeira
Nov 1, 2016·Cardiovascular and Interventional Radiology·Bedros TaslakianAmy Deipolyi
Jul 7, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Aysenur OzderyaKadriye Aydin
Mar 14, 2020·AJNR. American Journal of Neuroradiology·J L BeckerK Nael
Mar 3, 2020·Radiology and Oncology·Masa Majcen, Marko Hocevar
Jun 8, 2021·Radiology Research and Practice·Steven RaeymaeckersJohan De Mey
Jun 20, 2021·Head & Neck·Erin Weatherford CreightonBrendan C Stack

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
dissections

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.