Preoperative measurement of cutaneous melanoma and nevi thickness with photoacoustic imaging

Journal of Medical Imaging
Aedán BreathnachMartin J Leahy

Abstract

Photoacoustic imaging (PAI) is an emerging biomedical imaging technology, which can potentially be used in the clinic to preoperatively measure melanoma thickness and guide biopsy depth and sample location. We recruited 27 patients with pigmented cutaneous lesions suspicious for melanoma to test the feasibility of a handheld linear-array photoacoustic probe in imaging lesion architecture and measuring tumor depth. The probe was assessed in terms of measurement accuracy, image quality, and ease of application. Photoacoustic scans included single wavelength, spectral unmixing, and three-dimensional (3-D) scans. The photoacoustically measured lesion thickness gave a high correlation with the histological thickness measured from resected surgical samples ([Formula: see text], [Formula: see text] for melanomas, [Formula: see text], [Formula: see text] for nevi). Thickness measurements were possible for 23 of 26 cases for nevi and all (6) cases for melanoma. Our results show that handheld, linear-array PAI is highly reliable in measuring cutaneous lesion thickness in vivo, and can potentially be used to inform biopsy procedure and improve patient management.

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Citations

Feb 9, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mengyang Liu, Wolfgang Drexler
Feb 13, 2020·Journal of Biophotonics·Jenny HultMalin Malmsjö
Aug 24, 2019·Lasers in Surgery and Medicine·Ulf DahlstrandMalin Malmsjö
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May 15, 2021·Experimental Dermatology·Xosé Luís Deán-Ben, Daniel Razansky
Jul 11, 2021·Biosensors & Bioelectronics·Jinya DuHaifeng Dong

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