Abstract
To assess whether artificial neural network analysis (ANNA) predicts for positive surgical margins (PSMs) more effectively than logistic regression analysis (LRA) according to the combined use of the findings of pelvic coil magnetic resonance imaging (pMRI) and other preoperatively available tumor variables in patients with clinically organ-confined prostate cancer after radical prostatectomy. A total of 205 patients with clinically localized prostate cancer, who underwent retropubic radical prostatectomy were evaluated. The predictive variables included clinical TNM stage, prostate-specific antigen (PSA) level, PSA density, biopsy Gleason score, percentage of cancer in biopsy specimens, and pMRI findings. The predicted outcome was PSMs. The patient data were randomly split into four cross-validation sets and used to develop and validate the ANNA and LRA models. For comparison, the area under the receiver operating characteristic curve was used. The overall PSM rate was 22% (n = 45). Using all input parameters, the accuracy of the ANNA and LRA was 84% and 75% for the prediction of PSMs, respectively. The area under the receiver operating characteristic curve of the ANNA (0.872 +/- 0.014) was significantly greater statistically ...Continue Reading
References
Sep 1, 1983·Radiology·J A Hanley, B J McNeil
Jan 1, 1994·Annual Review of Medicine·G L Andriole, W J Catalona
Jul 1, 1995·The Journal of Urology·A V D'AmicoA Wein
Jul 1, 1993·The Journal of Urology·J I EpsteinP C Walsh
Dec 1, 1993·The Journal of Urology·D A AckermanB A Lowe
Nov 1, 1994·Radiology·E K OutwaterD G Mitchell
Dec 1, 1994·Radiology·H HricakP R Carroll
May 1, 1993·The American Journal of Surgical Pathology·P A Humphrey
Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A V D'AmicoA Wein
Jun 1, 1996·British Journal of Urology·F CornudJ F Moreau
Mar 1, 1996·The American Journal of Surgical Pathology·J I EpsteinP C Walsh
Nov 1, 1996·The Urologic Clinics of North America·J I Epstein
Mar 1, 1997·Radiology·K K YuC J Zaloudek
Nov 5, 1999·Cancer·L ChengD G Bostwick
May 5, 2000·Radiology·G J JagerJ O Barentsz
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L ChengD G Bostwick
Aug 8, 2001·Urology·M SouliéP Plante
Nov 25, 2003·The Journal of Urology·James A EasthamPeter T Scardino
Jan 31, 2004·Urology·Brett A LavenCharles B Brendler
Citations
Apr 18, 2007·BJU International·PierFrancesco BassiAndrea Volpe
Apr 29, 2006·European Journal of Cancer Care·E BartfayJ L Pater
Dec 15, 2004·Urology·Vassilis PoulakisEduard Becht
Aug 2, 2005·European Urology·Wolfgang DillenburgEduard Becht
Oct 30, 2016·Urologia·Lorenzo BianchiAlberto Briganti
Feb 13, 2013·Nature Reviews. Urology·Xinhai HuCarsten Stephan
Jul 6, 2021·The Prostate·Mithat EkşiAli I Taşçı
Jul 24, 2021·BMC Medical Informatics and Decision Making·Hesham SalemAmir Awwad