Preoperative Neutrophil Lymphocyte Ratio Can Be Used as a Predictor of Prognosis in Patients With Adenocarcinoma of the Esophagogastric Junction: A Systematic Review and Meta Analysis

Frontiers in Oncology
Xiao-Bo LiuSheng-Bao Li

Abstract

Objective: Neutrophil lymphocyte ratio (NLR), Lymphocyte mononuclear cell ratio (LMR), and Platelet lymphocyte ratio (PLR) can be used as various prognostic factors for malignant tumors, but the value of prognosis for patients with adenocarcinoma of the esophagogastric junction (AEG) has not been determined. This study used meta-analysis to assess the value of these indicators in the evaluation of AEG prognosis. Methods: Relevant literatures on the prognostic relationship between NLR, LMR, PLR, and AEG was retrieved from PubMed, Web of Science, Embase, Cochrane Library, Cochrane Central Register of Controlled Trials, Wanfang data, and Chinese National Knowledge Infrastructure. The search time from database establishment to June 30, 2019. The language is limited to English and Chinese. Data was analyzed using Stata 15.0 software. Result: Six retrospective studies were included, five of them involved NLR and six of them involved PLR. No LMR literature that adequately satisfied the conditions was retrieved. Increased NLR was significantly associated with a significant reduction in overall survival (OS), cancer-specific survival (CSS), or disease specific survival (DSS) in patients with AEG [hazard ratio (HR) = 1.545, 95% CI: 1.096...Continue Reading

References

Nov 21, 1998·The British Journal of Surgery·J R Siewert, H J Stein
Apr 17, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·J. R. Siewert
Oct 20, 2004·British Journal of Pharmacology·Paul JuraszMarek W Radomski
Dec 22, 2009·Future Oncology·Campbell S D Roxburgh, Donald C McMillan
Nov 3, 2010·Journal of Thrombosis and Haemostasis : JTH·N M Bambace, C E Holmes
Dec 15, 2010·World Journal of Gastroenterology : WJG·Paul-M Hofman
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A P Thrift, D C Whiteman
Nov 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·A DubeczJ H Peters
Apr 4, 2014·Cancer Metastasis Reviews·David G MenterKenneth V Honn
Jan 23, 2015·Oncoimmunology·Giuseppe SconocchiaSoldano Ferrone
Jul 15, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M MessagerW H Allum
Jun 11, 2016·Nature Reviews. Cancer·Seth B CoffeltKarin E de Visser
Dec 13, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Lance L Munn
Mar 21, 2017·Zhonghua zhong liu za zhi [Chinese journal of oncology]·W J ZhouC P Wu
Apr 21, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Waku HattaTakuji Gotoda
Dec 30, 2017·ORAL & Implantology·D LauritanoF Carinci
May 29, 2018·International Journal of Surgery·Dewen TanFan Li
Jul 22, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gang HuRu-Jin Hu
Feb 11, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lixiao Yang, Huixiao Chen
May 22, 2019·Zhongguo fei ai za zhi = Chinese journal of lung cancer·Haoran ChenHongjun Gao
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A P Thrift, D C Whiteman

❮ Previous
Next ❯

Citations

Jan 6, 2021·ESMO Open·M NakanoUNKNOWN Kurume Liver Cancer Study Group of Japan

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.