Preoperative neutrophil-to-lymphocyte ratio predicts recurrence of patients with single-nodule small hepatocellular carcinoma following curative resection: a retrospective report

World Journal of Surgical Oncology
Rui LiaoCheng-You Du

Abstract

Preoperative neutrophil-to-lymphocyte ratio (NLR) has been identified as a predictor for the recurrence of hepatocellular carcinoma (HCC), but the cut-off of NLR is inconsistent in various studies. Thus, we detected the prognostic value of preoperative NLR in the single-nodule small HCC (SHCC) patients using X-tile for cutpoint. Between January 2007 and December 2010, a total of 222 single-nodule SHCC patients underwent curative resection and were examined for the prognostic roles of preoperative NLR by X-tile. In this study, all patients were divided into the low-NLR subgroup (NLR ≤ 2.1) and the high-NLR subgroup (NLR > 2.1) by X-tile. Preoperative NLR showed predictive value for time to recurrence (TTR) and overall survival (OS). Moreover, NLR was associated with total bilirubin, white blood cell counts, and HBsAg, respectively (P = 0.012, <0.001, and 0.011, respectively). Especially, NLR could discriminate the outcome of patients in the subgroup with alpha-fetoprotein (AFP) levels of ≤400 ng/mL. Importantly, postoperative transcatheter arterial chemoembolization (TACE) had close relationship with OS (P = 0.001) and TTR (P ≤ 0.001). Therefore, this study indicates that preoperative NLR, divided by X-tile for the cutpoint, is ...Continue Reading

References

Jun 1, 1994·Journal of the National Cancer Institute·D G AltmanM Schumacher
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Feb 3, 2005·Journal of Gastroenterology and Hepatology·Yoshihito ImaiKazuichi Okazaki
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki NozawaDouglas Hanahan
Feb 13, 2007·Cancer Cell·Alexander HoffmannInder M Verma
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Sep 11, 2008·Journal of Cancer Research and Clinical Oncology·Yi-Wei LiXiao-Wu Huang
Oct 17, 2008·The New England Journal of Medicine·Morris Sherman
May 12, 2009·International Journal of Cancer. Journal International Du Cancer·Braedon McDonaldLorenzo E Ferri
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hila BarashRinat Abramovitch
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Nov 6, 2010·Science·Hans Schreiber, Donald A Rowley
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ronnie T P Poon
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian ZhouJia Fan
Feb 14, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liping ChenGuangwen Cao
Oct 17, 2012·CA: a Cancer Journal for Clinicians·Mary Maluccio, Anne Covey
Nov 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yun-Fan SunJia Fan
Jan 12, 2013·Journal of Experimental & Clinical Cancer Research : CR·Rui LiaoShuang-Jian Qiu
Jan 15, 2013·Gastroenterology·Virginia Hernandez-GeaJosep M Llovet
Apr 23, 2013·Journal of Experimental & Clinical Cancer Research : CR·Rui LiaoShuang-Jian Qiu

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Citations

May 4, 2016·World Journal of Surgery·Mitsugi ShimodaKeiichi Kubota
Aug 12, 2017·Gastroenterology Research and Practice·Jue-Rong FengJin Li
May 20, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rui LiaoMing Li
Sep 22, 2020·World Journal of Gastroenterology : WJG·Ayman Bannaga, Ramesh P Arasaradnam

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Methods Mentioned

BETA
surgical resection
X-tile

Software Mentioned

tile
SPSS

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