Preoperative positive voided urine cytology predicts poor clinical outcomes in patients with upper tract urothelial carcinoma undergoing nephroureterectomy.

BMC Cancer
Wen LiuGuiming Zhang

Abstract

Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urine cytology (VUC) on UTUC prognosis, compared with negative VUC, has not been fully demonstrated. This study aimed to evaluate the impact of preoperative VUC on predicting intravesical recurrence, disease recurrence, and mortality in patients with UTUC who underwent nephroureterectomy (RNU). Clinicopathological information was collected from 315 UTUC patients treated with RNU. The association between VUC and oncological outcomes was analyzed using the Kaplan-Meier method with log-rank test and Cox proportional hazards regression models. Multiple logistic regression analysis was performed to identify the influence of VUC on tumor grade. Preoperative positive VUC, presenting in 101 patients (32%), was significantly associated with tumor multifocality (P = 0.017) and higher tumor grade (P = 0.010). On multivariable Cox regression analyses, preoperative positive VUC was an independent prognostic factor of intravesical recurrence-free survival (RFS) (hazard ratio [HR] = 2.21, 95% confidence interval [CI] 1.06-4.64; P = 0.035), R...Continue Reading

References

Dec 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eiji KikuchiShahrokh F Shariat
Sep 6, 2013·Japanese Journal of Clinical Oncology·Akihiro ItoUNKNOWN Tohoku Urological EBM Study Group
Aug 26, 2014·European Urology·Guillaume PloussardWassim Kassouf
Jun 5, 2016·The Surgical Clinics of North America·Gabriella J AvellinoDavid S Wang
Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner

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