Preoperative Prediction of Lymph Nodal Metastases in Endometrial Carcinoma: Is it Possible?: A Literature Review

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Rami FaresNazem Shams

Abstract

Lymph node status is one of the most important prognostic factors in endometrial cancer and crucial for deciding adjuvant therapy. The aim of the study was to assess the different models used to predict lymphatic nodal disease. A literature search was conducted to detect the relevant studies. Relevant papers comparing the preoperative modality with the final histopathological results including randomized clinical trials, case-control studies, and any publications with a minimum of 50 patients in the report. Molecular-based predictors are still far from a practical application. Preoperative radiological scans (positron emission tomography, computed tomography, magnetic resonance imaging, and ultrasound) have shown the best predictor of lymphatic dissemination. However, there is currently no ideal model available, which can be used within standard clinical care. Surgical staging still remains the criterion standard in the determination of lymph node status in endometrial cancer.

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