Preoperative predictors for residual tumor after surgery in patients with ovarian carcinoma

Oncology
D de JongA C Ansink

Abstract

Suboptimal debulking (>1 cm residual tumor) results in poor survival rates for patients with an advanced stage of ovarian cancer. The purpose of this study was to develop a prediction model, based on simple preoperative parameters, for patients with an advanced stage of ovarian cancer who are at risk of suboptimal cytoreduction despite maximal surgical effort. Retrospective analysis of 187 consecutive patients with a suspected clinical diagnosis of advanced-stage ovarian cancer undergoing upfront debulking between January 1998 and December 2003. Preoperative parameters were Karnofsky performance status, ascites and serum concentrations of CA 125, hemoglobin, albumin, LDH and blood platelets. The main outcome parameter was residual tumor >1 cm. Univariate and multivariate logistic regression was employed for testing possible prediction models. A clinically applicable graphic model (nomogram) for this prediction was to be developed. Serum concentrations of CA 125 and blood platelets in the group with residual tumor >1 cm were higher in comparison to the optimally cytoreduced group (p < 0.0001 and <0.01, respectively). Serum albumin and hemoglobin levels were lower in the group with residual tumor (p < 0.0001 and <0.05, respective...Continue Reading

References

Nov 1, 1990·Statistics in Medicine·J C Van Houwelingen, S Le Cessie
Nov 1, 1989·Human Reproduction·R G Edwards
Mar 1, 1982·Clinical Radiology·H Mamtora, I Isherwood
Oct 1, 1994·British Journal of Obstetrics and Gynaecology·D ParkerJ J Price
Apr 1, 1994·Gynecologic Oncology·P E SchwartzR Makuch
Dec 16, 1998·British Journal of Obstetrics and Gynaecology·R BellT Sheldon
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GattaA Verdecchia
Jul 7, 2000·Seminars in Surgical Oncology·I VergoteP Van Dam
Aug 8, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·U Menon, I J Jacobs
Aug 25, 2001·Gynecologic Oncology·D S ChiW J Hoskins
Jul 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S. GroverM. Cauchi
Sep 10, 2002·The Lancet Oncology·Mark Harries, Martin Gore
Jul 11, 2003·Critical Reviews in Oncology/hematology·Simon Jean-Pierre Van Belle, Véronique Cocquyt
Dec 4, 2003·Journal of the American College of Surgeons·Philippe MoriceDamienne Castaigne
Feb 7, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E C BrockbankJ E Bridges
Jul 24, 2004·Expert Review of Anticancer Therapy·Tjoung-Won Park, Walther C Kuhn
Oct 20, 2004·Gynecologic Oncology·Gamal H EltabbakhAnne Morgan
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I VergoteP Neven
Oct 6, 2005·Gynecologic Oncology·Scott M EisenkopWei-Chien Michael Lin
Dec 13, 2006·Gynecologic Oncology·Giovanni D AlettiWilliam A Cliby

❮ Previous
Next ❯

Citations

Feb 6, 2013·Nature Reviews. Clinical Oncology·Robert L ColemanThomas J Herzog
Dec 22, 2009·Future Oncology·Campbell S D Roxburgh, Donald C McMillan
Aug 8, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Carsten Lindberg Fagö-OlsenClaus Hoegdall
Apr 29, 2015·Gynecologic Oncology·Jo Marie Tran JancoJamie N Bakkum-Gamez
Sep 25, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C FotopoulouJ Sehouli
Apr 10, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Carsten L Fagö-OlsenClaus Høgdall
Feb 27, 2010·Journal of Surgical Oncology·Lori E WeinbergJean A Hurteau
Apr 1, 2009·Seminars in Oncology·Carolyn Krasner, Linda Duska
Jun 12, 2013·Gynecologic Oncology·S K AllensworthJ N Bakkum-Gamez
Dec 31, 2009·Journal of Gynecologic Oncology·Mark A RettenmaierBram H Goldstein
Jan 9, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Philipp HarterAndreas du Bois
Dec 4, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Signe RisumClaus Høgdall
Feb 4, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·C G GeresteinA C Ansink
Jul 31, 2019·American Journal of Clinical Oncology·Vasilios PergialiotisAlexandros Rodolakis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
Ali AminianAlireza Mirsharifi
The Journal of Clinical Investigation
Gaorav P Gupta, Joan Massagué
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Andrew J Li, Beth Y Karlan
© 2021 Meta ULC. All rights reserved