Preoperative radiologic classification of convexity meningioma to predict the survival and aggressive meningioma behavior

PloS One
Yi LiuJun Pan

Abstract

A subgroup of meningioma demonstrates clinical aggressive behavior. We set out to determine if the radiological parameters can predict histopathological aggressive meningioma, and propose a classification to predict survival and aggressive meningioma behavior. A retrospective review of medical records was conducted for patients who underwent surgical resection of their convexity meningioma. WHO-2007 grading was used for histopathological diagnosis. Preoperative radiologic parameters were analyzed, each parameter was scored 0 or 1. Signal intensity on diffusion weighted MRI (DWI) (hyperintensity=1), heterogeneity on T1-weighted gadolinium enhanced MRI (heterogeneity=1), disruption of arachnoid at brain-tumor interface=1 and peritumoral edema (PTE) on T2-weighted MRI (presence of PTE=1) and tumor shape (irregular shape=1). Multivariate logistic regression analyses were conducted to determine association of radiological parameters to histopathological grading. Kaplan-Meier and Cox regression models were used to determine the association of scoring system to overall survival and progression free survival (PFS). Reliability of the classification was tested using Kappa co-efficient analysis. Hyperintensity on DWI, disruption of arach...Continue Reading

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Citations

Nov 18, 2017·PloS One·Thibaud P CorollerHugo J W L Aerts
May 31, 2019·Acta neurochirurgica·Eileen Maria Susanne StreckertBenjamin Brokinkel
Jan 17, 2019·Neuro-oncology·Raymond Y HuangUNKNOWN International Consortium on Meningiomas
Jan 4, 2017·Clinical Sarcoma Research·Catherine McCarthyNick A Athanasou

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Methods Mentioned

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surgical resection

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SPSS

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