PMID: 7523342Sep 30, 1994Paper

Preoperative serum prostate-specific antigen and Gleason grade as predictors of pathologic stage in clinically organ confined prostate cancer: implications for the choice of primary treatment

International Journal of Radiation Oncology, Biology, Physics
R D EnnisR E Peschel

Abstract

Despite careful preoperative staging, approximately 50% of patients who undergo radical prostatectomy for clinical stage A2 (T1b-c) and B (T2) prostate cancer are found to have pathologic stage C (T3-4) or D (N1) disease. This study investigates whether preoperative serum prostate specific antigen (PSA) and Gleason grade predict pathologic stage among patients with clinically organ confined prostate cancer. The records of all 63 patients who underwent attempted pelvic lymphadenectomy and radical prostatectomy for adenocarcinoma of the prostate at our institution in 1990-91 were retrospectively reviewed. Patients with a preoperative serum PSA of 12.5 ng/mL or greater had an 81% incidence of pathologic upstaging to stage C (T3-4) or D (N1) compared with 38% for patients with a PSA less than 12.5 (p = 0.0015). The incidence of various pathologic findings for prostate specific antigen > or = 12.5 vs. prostate specific antigen < 12.5 was as follows: seminal vesicle involvement 29% vs. 5% (p = 0.0186), lymph node metastases 24% vs. 0% (p = 0.0029), capsular penetration 71% vs. 38% (p = 0.0424), and positive margins 47% vs. 36% (p = 0.56). None (0/3) of the patients with Gleason grade 4 or less were pathologically upstaged compared wi...Continue Reading

Citations

Jan 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G M DuchesneP Wall
May 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A V D'AmicoD Schultz
Jun 1, 1996·Urology·A E KatzR Buttyan
Jul 17, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurent SalomonJean-Leon Lagrange
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·M ZaiderJ A Koutcher
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T M PisanskyH Zincke
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·R E Peschel
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·S P LankfordG K Zagars
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
May 7, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K FujikawaM Sasaki
Jun 19, 2013·Journal of Clinical Pathology·Michelle R DownesTheodorus H van der Kwast
Sep 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R E Peschel
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin A SpencerMark S Litwin

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