Preoperative small-dose ketamine prevented tourniquet-induced arterial pressure increase in orthopedic patients under general anesthesia

Anesthesia and Analgesia
T SatsumaeH Kida

Abstract

The mechanism of tourniquet-induced arterial pressure increase is not known. We investigated the effect of preoperative ketamine on tourniquet-induced arterial pressure and heart rate changes in 85 patients undergoing knee surgery with a tourniquet under general anesthesia. Patients were randomly assigned into three groups; Large Ketamine (n = 28; ketamine 1.0 mg/kg), Small Ketamine (n = 28; ketamine 0.25 mg/kg), and Control (n = 29; normal saline) groups. Anesthesia was maintained with 1.5%-2.5% sevoflurane and 66% N(2)O in oxygen with endotracheal intubation. Ketamine or normal saline was given in a double-blinded fashion before skin incision and tourniquet inflation. Arterial pressure and heart rate were recorded every 10 min until 60 min after the start of tourniquet inflation and again after deflation. Arterial pressure and heart rate were compared among the three groups by using repeated-measures analysis of variance. In the Large and Small Ketamine groups, arterial pressure was not significantly changed, but in the Control group arterial pressure was significantly increased 40, 50, and 60 min after the start of tourniquet inflation (P < 0.05). Development of more than a 30% increase in systolic arterial pressure during t...Continue Reading

References

Mar 1, 1982·British Journal of Anaesthesia·R D Kaufman, L F Walts
Dec 1, 1993·Anesthesia and Analgesia·L RoytblatA Fisher
Oct 3, 1998·Brain Research·L B Wilson, A D Crews

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Citations

Dec 16, 2010·European Journal of Anaesthesiology·Mustafa N AbduşoğluHilal Ayoğlu
Oct 12, 2012·Journal of Anesthesia·Tsuyoshi SatsumaeMakoto Tanaka
May 4, 2013·The Kaohsiung Journal of Medical Sciences·Yao LuGordon Tin-Chun Wong
Sep 29, 2007·The Journal of International Medical Research·J-W ParkS-M Cha
Jan 26, 2013·The Kaohsiung Journal of Medical Sciences·Evrim BostankoluIsil Ozkocak Turan
Mar 13, 2015·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jui-Yang Hsieh, Hui-Wen Lin
Aug 24, 2005·Anesthesia and Analgesia·Aygun GulerMeral Kanbak

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