Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study

The Journal of Thoracic and Cardiovascular Surgery
Leslie L ClarkFrancis G Spinale

Abstract

Cardiac surgical procedures can be associated with significant morbidity and mortality. Recently, it has been recognized that statins might induce multiple biologic effects independent of lipid lowering that could potentially ameliorate adverse surgical outcomes. Accordingly, this study tested the central hypothesis that pretreatment with statins before cardiac surgery would reduce adverse postoperative surgical outcomes. Demographic and outcomes data were collected retrospectively for 3829 patients admitted for planned cardiac surgery between February 1994 and December 2002. Statin pretreatment occurred in 1044 patients who were comparable with non-statin-pretreated (n = 2785) patients with regard to sex, race, and age. Primary outcomes examined included postoperative mortality (30-day) and a composite morbidity variable. The odds of experiencing 30-day mortality and morbidity were significantly less in the statin-pretreated group, with unadjusted odds ratios of 0.43 (95% confidence interval [CI], 0.28-0.66) and 0.72 (95% CI, 0.61-0.86), respectively. Risk-adjusted odds ratios for mortality and morbidity were 0.55 (95% CI, 0.32-0.93) and 0.76 (95% CI, 0.62-0.94), respectively, by using a logistic regression model and 0.51 (95%...Continue Reading

References

Jun 1, 1991·Journal of Cardiac Surgery·S V LichtensteinT A Salerno
Mar 4, 1998·The Annals of Thoracic Surgery·F G EstafanousN J Starr
Dec 5, 1998·The New England Journal of Medicine·UNKNOWN Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
Nov 14, 2000·The American Journal of Cardiology·M I DotaniC M Gibson
Oct 25, 2002·The New England Journal of Medicine·Dennis T Mangano, UNKNOWN Multicenter Study of Perioperative Ischemia Research Group
Apr 5, 2003·Drug News & Perspectives·Sven Wassmann, Georg Nickenig
May 29, 2003·The Journal of Thoracic and Cardiovascular Surgery·Harold L LazarSheilah A Bernard
Jun 26, 2003·The Annals of Thoracic Surgery·A Laurie W ShroyerUNKNOWN Society of Thoracic Surgeons
Sep 17, 2003·Circulation·Scott KinlayUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering Study Investigators
Dec 12, 2003·The Annals of Thoracic Surgery·José Pablo WerbaAlessandro Parolari
Feb 5, 2004·The Annals of Thoracic Surgery·Sheila C GardnerA Laurie Shroyer
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Panayiotis A EconomidesAristidis Veves
Jun 3, 2004·Annals of Internal Medicine·Frederick A SpencerUNKNOWN GRACE Investigators
Jun 17, 2004·Circulation·Jean Davignon
Jul 28, 2004·The Annals of Thoracic Surgery·Harold L Lazar
Nov 9, 2004·Atherosclerosis. Supplements·T R PedersenUNKNOWN Scandinavian Simvastatin Survival Study Group
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

❮ Previous
Next ❯

Citations

Aug 5, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marie-Claude Parent, Stéphane Rinfret
Nov 3, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nader N Boushra, Muhammad Muntazar
Dec 31, 2008·The Journal of Thoracic and Cardiovascular Surgery·Minoru TabataJames D Rawn
Dec 31, 2008·The Journal of Thoracic and Cardiovascular Surgery·Vito A MannacioF Musumeci
Apr 9, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elmar W KuhnThorsten Wahlers
Feb 26, 2010·Journal of Cardiothoracic Surgery·James A MagovernGeorge J Magovern
Jan 21, 2012·The Korean Journal of Thoracic and Cardiovascular Surgery·Young-Nam YounKyung-Jong Yoo
Aug 14, 2009·Expert Opinion on Drug Safety·Alexander Kulik, Marc Ruel
Apr 15, 2014·The Annals of Thoracic Surgery·Amber O MolnarUNKNOWN TRIBE-AKI Consortium
Jan 1, 2013·The American Journal of Cardiology·J Bradley LaytonM Alan Brookhart
Nov 16, 2010·Anesthesiology Clinics·Phillip L KalarickalAlan D Kaye
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Oliver J LiakopoulosThorsten Wahlers
Oct 23, 2008·The American Journal of Cardiology·Salim S ViraniChristie M Ballantyne
May 23, 2008·Best Practice & Research. Clinical Anaesthesiology·Georgina Howard-AlpeBruce Biccard
Nov 3, 2007·The Journal of Thoracic and Cardiovascular Surgery·Matthias ThielmannHeinz Jakob
Nov 28, 2006·The Annals of Thoracic Surgery·Giangiuseppe CappabiancaLuigi de Luca Tupputi Schinosa
Jul 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Charles D CollardUNKNOWN Ischemia Research and Education Foundation (IREF) Investigators
Feb 23, 2010·The Annals of Thoracic Surgery·Michael A BorgerFriedrich W Mohr
Apr 30, 2008·The Annals of Thoracic Surgery·Lynn M FedorukKaren C Johnston
Sep 23, 2014·The Journal of Thoracic and Cardiovascular Surgery·Ashraf A SabeFrank W Sellke
Oct 9, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Imad M TleyjehLarry M Baddour
Mar 4, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe PattiKausik K Ray
Mar 7, 2006·The Journal of Thoracic and Cardiovascular Surgery·Harold L Lazar
Jan 27, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Xiaocheng ChengXuewen Tang
Mar 19, 2008·Journal of Clinical Anesthesia·Kathirvel SubramaniamNorman J Starr
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Russell E AndersonTorbjörn Ivert
Aug 23, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·David Bronheim
May 25, 2016·The Cochrane Database of Systematic Reviews·Elmar W KuhnOliver J Liakopoulos
Mar 12, 2015·The Cochrane Database of Systematic Reviews·Michelle LewickiAntoine G Schneider
Feb 14, 2015·Circulation·Alexander KulikUNKNOWN American Heart Association Council on Cardiovascular Surgery and Anesthesia
Oct 15, 2008·Circulation·Alexander KulikNiteesh K Choudhry
Sep 8, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Alberto RadaelliAlberto U Ferrari
Jan 11, 2007·Current Opinion in Anaesthesiology·Lawrence Blanchard, Charles D Collard

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