Preoperative statin treatment is associated with reduced postoperative mortality after isolated cardiac valve surgery in high-risk patients

Journal of Cardiothoracic and Vascular Anesthesia
Nicolas AllouIvan Philip

Abstract

The aim of the present study was to assess the influence of preoperative statin therapy on postoperative mortality in high-risk patients after isolated valve surgery. An observational cohort study. A 1,200-bed university hospital. All consecutive patients undergoing isolated nonemergent valve surgery with cardiopulmonary bypass between November 2005 and December 2007 were included. None. During the period, 772 consecutive patients underwent nonemergent isolated valve surgery. Among them, 430 were high cardiovascular risk (defined by patients with 2 or more cardiovascular risk factors). In the high-risk cardiovascular patients, statin pretreatment was administered in 222 patients (52%). In multivariate analysis, after adjustment with a propensity score analysis, preoperative statin therapy was associated with a significant reduction of postoperative mortality in patients with high risk (odds ratio = 0.41; 95% confidence interval, 0.17-0.97; p = 0.04). Low left ventricular ejection fraction and elevated pulmonary artery pressure also were independently associated with increased postoperative mortality. By contrast, in the low-risk patient group, few patients received preoperative statin therapy (7%). This study suggests that preo...Continue Reading

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Citations

Apr 9, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Elmar W KuhnThorsten Wahlers
Sep 3, 2013·The Annals of Thoracic Surgery·Elmar W KuhnThorsten Wahlers
Jun 25, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Rabi YacoubPradeep Arora
Oct 4, 2011·Journal of Cardiothoracic and Vascular Anesthesia·John G T Augoustides
Feb 8, 2014·Renal Failure·Song Mao, Songming Huang
Jan 27, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Xiaocheng ChengXuewen Tang
Aug 9, 2016·International Journal of Cardiology·Minxiong LiGaosi Xu
Nov 17, 2020·Asian Cardiovascular & Thoracic Annals·Atul KaushikPravin K Goel
Aug 15, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Yu TianJia Liu

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