Preoperative thyroid function and weight loss after bariatric surgery

International Journal of Obesity : Journal of the International Association for the Study of Obesity
João Sérgio NevesAMTCO Group

Abstract

Thyroid function has an important role on body weight regulation. However, the impact of thyroid function on weight loss after bariatric surgery is still largely unknown. We evaluated the association between preoperative thyroid function and the excess weight loss 1 year after surgery, in 641 patients with morbid obesity who underwent bariatric surgery. Patients with a history of thyroid disease, treatment with thyroid hormone or antithyroid drugs and those with preoperative evaluation consistent with overt hypothyroidism or hyperthyroidism were excluded. The preoperative levels of TSH and FT4 were not associated with weight loss after bariatric surgery. The variation of FT3 within the reference range was also not associated with weight loss. In contrast, the subgroup with FT3 above the reference range (12.3% of patients) had a significantly higher excess weight loss than patients with normal FT3. This difference remained significant after adjustment for age, sex, BMI, type of surgery, TSH and FT4. In conclusion, we observed an association between high FT3 and a greater weight loss after bariatric surgery, highlighting a group of patients with an increased benefit from this intervention. Our results also suggest a novel hypothe...Continue Reading

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Citations

Sep 3, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Emanuele MuracaGianluca Perseghin
Oct 10, 2020·Metabolism: Clinical and Experimental·Robert DentMary-Ellen Harper
Apr 17, 2021·International Journal of Endocrinology·Sanjay KalraDeepak Khandelwal
Mar 12, 2021·The Journal of Clinical Endocrinology and Metabolism·Emanuele MuracaMatteo Villa

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