PMID: 9551689Apr 29, 1998Paper

Preoperative TNM-classification is a better prognostic indicator for recurrence of hepatocellular carcinoma after liver transplantation than albumin mRNA in peripheral blood. Liver Transplant Oncology Group

Journal of Hepatology
M Peck-RadosavljevicF Mühlbacher

Abstract

Survival after orthotopic liver transplantation for hepatocellular carcinoma is limited by a high rate of tumor recurrence. A polymerase chain reaction assay based on the detection of albumin mRNA expression in peripheral blood for detection of hematogenous micrometastasis of hepatocellular carcinoma has been described, which may help to select candidates for orthotopic liver transplantation. The prognostic value of a highly sensitive nested reverse transcription-polymerase chain reaction assay was evaluated in comparison with the TNM-classification of the International Union against Cancer in a population of liver transplant candidates. Eighty patients with liver disease and 42 control patients were evaluated. Six of 21 patients with hepatocellular carcinoma and 11 of 59 patients with other diseases of the liver were positive for albumin reverse transcription-polymerase chain reaction, making this assay an indicator of ongoing liver damage without absolute specificity for hepatocellular carcinoma. Twelve patients with hepatoma were followed after liver transplantation and seven of those patients had a tumor recurrence within 12 months. Six of these patients with recurrence had International Union against Cancer stage IV A tumo...Continue Reading

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Apr 17, 1999·The New England Journal of Medicine·C M Clay
Jan 26, 2002·The American Journal of Gastroenterology·Cathey H CawthorneClaus J Fimmel
Jul 3, 2004·Journal of Viral Hepatitis·G V Papatheodoridis, E Cholongitas
Oct 17, 2009·Clinical Chemistry·Rebecca W Y ChanRossa W K Chiu
Jul 9, 2004·World Journal of Gastroenterology : WJG·Li ZhaoJi-Ye Zhu

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