Preoperative transfusion versus no transfusion policy in sickle cell disease patients: a randomized trial.

Transfusion
Mohamed ElshinawyYasser Wali

Abstract

Many children with sickle cell disease (SCD) indicated for adenotonsillectomy receive pre-operative transfusion therapy, either simple or exchange transfusion, in order to reduce surgical and sickle cell disease-related complications. This is a prospective randomized controlled clinical trial aiming to compare between preoperative simple transfusion and no transfusion in pediatric patients with sickle SCD admitted in Sultan Qaboos University Hospital, Muscat, Oman for adenotonsillectomy during the period from January 2014 through June 2018. They were randomly assigned into two arms (simple transfusion and no transfusion). Postoperative SCD-related complications have been encountered in 6 out of 138 patients (4.3%). There was no statistically significant difference between the two studied groups as regards the development of surgical or SCD-related complications (p = 0.6 and 0.8 respectively). The length of postoperative hospital stay was comparable in the two groups. (p = 0.607). SCD-related complications occurred exclusively in cases with homozygous sickle anemia (4 out of 81 = 4.9%). Sickle cell disease patients with a hemoglobin level above 7.5 g/dL do not need PRBCs transfusion prior to adenotonsillectomy. This approach did...Continue Reading

References

May 1, 1996·Journal of Pediatric Hematology/oncology·L J BrooksB W Berman
Jul 1, 1997·Archives of Otolaryngology--head & Neck Surgery·D J HalvorsonE S Porubsky
Jun 23, 2004·Clinical Pediatrics·Jeffrey Peterson, Joseph D Losek
Feb 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Rebecca L DukeValerie A Flanary
Feb 17, 2007·Transfusion·Patrick DaviesPeter Davis
Feb 27, 2009·Current Opinion in Pediatrics·Shannon Wahl, Keith C Quirolo
Jun 6, 2009·Jornal de pediatria·Cristina SallesMarcos Almeida Matos
Oct 1, 2010·Paediatric Anaesthesia·Paul G FirthSalvatore R Goodwin
Jul 3, 2013·Cold Spring Harbor Perspectives in Medicine·Graham R Serjeant
Apr 5, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Richard A Armstrong
Sep 10, 2014·JAMA : the Journal of the American Medical Association·Barbara P YawnJoylene John-Sowah
Dec 18, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·A-C Hessén SödermanJ Stalfors
Dec 4, 2016·Hematology·Jo Howard
May 15, 2018·Mediterranean Journal of Hematology and Infectious Diseases·Kwame Ofori AdjepongYaw Amoateng Adjepong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.