Preoperative treatment with recombinant human growth hormone prevents ischemia reperfusion-induced diaphragmatic dysfunction

The Journal of Surgical Research
D MoneleyD J Bouchier Hayes

Abstract

Respiratory complications continue to be a major cause of morbidity and mortality following major vascular surgery. The recent UK Small Aneurysm Trial cited preoperative respiratory function as the major predictor of outcome following elective aortic surgery. The aim of this study was to investigate the effect of aortic clamping and revascularization on diaphragmatic muscle function in a small animal model and to evaluate the role of preoperative treatment with recombinant human growth hormone (rhGH) in preventing diaphragmatic muscle dysfunction. Male Sprague-Dawley rats (n = 18) were randomized into one of three groups: control (n = 6) underwent laparotomy only; IR (n = 6) had a laparotomy with infrarenal cross-clamping for 30 min followed by lower torso revascularization for 2 h; IR + rhGH (n = 6) were treated with rhGH (Genotropin 0.3 IU/kg/day) for 5 days before laparotomy and aortic cross-clamping for 30 min followed by lower torso revascularization for 2 h. Diaphragmatic muscle contractile function was assessed ex vivo using electrical field stimulation in a tissue bath. Two hours of IR injury resulted in a significant impairment in diaphragmatic twitch (Control, 242.01 + 38.45 g; IR, 108.55 + 7.15 g). This impairment wa...Continue Reading

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y FongS F Lowry
Jun 1, 1996·American Journal of Surgery·J B KnoxA A Santos
Feb 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M C BarryD B Hayes
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·H KatagiriP A Easton
Nov 18, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M C BarryD Bouchier Hayes
Sep 9, 1999·The New England Journal of Medicine·J TakalaC J Hinds

❮ Previous
Next ❯

Citations

Mar 26, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ahmet AkkocaNizamettin Dalkilic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

Critical Care Clinics
Teng Teng Chung, C J Hinds
Journal of the American College of Radiology : JACR
Raymond BertinoJames L Swischuk
European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
E C VourvouriJ R Roelandt
Seminars in Interventional Radiology
H Bob SmouseJames L Swischuk
© 2021 Meta ULC. All rights reserved