Preoperative tumor marker doubling time is a useful predictor of recurrence and prognosis after hepatic resection of hepatocellular carcinoma

Journal of Surgical Oncology
Toshiro MasudaHideo Baba

Abstract

It is important to identify prognostic factors in patients with hepatocellular carcinoma (HCC) before hepatectomy. No previous studies have addressed the predictive efficacy of the preoperative doubling times of alpha-fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA-II). A total of 210 HCC patients who underwent a hepatic resection between 1998 and 2006 were prospectively evaluated. Serum AFP and PIVKA-II levels were measured at least twice before surgery to calculate the doubling times. Nineteen clinical factors that can be examined preoperatively, including the doubling times of AFP and PIVKA-II were investigated to identify prognostic factors for disease-free and overall survival after hepatectomy. There was no relationship between preoperative levels and doubling times of AFP and PIVKA-II. In a multivariate analysis, patients with a doubling time of AFP ≤30 days and PIVKA-II ≤16 days showed a significantly worse disease-free (P = 0.02, P = 0.03, respectively) and overall survival (P < 0.0001, P = 0.03, respectively). In HCC patients, the doubling times of preoperative serum AFP or PIVKA-II levels are useful tools to predict early postoperative recurrence and a poor prognosis.

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Citations

Aug 8, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amit TiroshElectron Kebebew
Sep 15, 2015·Surgical Case Reports·Kunitaka KuramotoHideo Baba
Jul 24, 2012·International Journal of Clinical Oncology·Kei HorinoHideo Baba
Nov 20, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shigeki NakagawaHideo Baba
Apr 25, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yu SaitoMichihito Asanoma
Mar 22, 2014·Molecular and Clinical Oncology·Naoki ShingakiMasao Ichinose
Jul 11, 2018·World Journal of Clinical Cases·Narongsak RungsakulkijSuraida Aeesoa
Aug 11, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masayo TsukamotoHideo Baba
Feb 9, 2021·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hong-Lin ChenBin Zhu

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