Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls

Intestinal research
Paulo Gustavo KotzeRemo Panaccione

Abstract

Recent advances in medical and surgical therapy were achieved during the last two decades in the management of Crohn's disease (CD). Anti-tumor necrosis factor (anti-TNF) agents are widely used worldwide. However, a significant proportion of patients still need surgical resections. The impact of previous exposure to these agents on the perioperative and postoperative outcomes is still controversial. In this critical review, we aimed to position the strategy of intentional preoperative use of anti-TNF agents in the management of CD. The indications and contraindications for this strategy are detailed, and despite scarce evidence, the possible advantages and disadvantages of the intentional use of anti-TNF agents before abdominal surgery in CD are discussed.

References

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Citations

Feb 23, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Geom Seog Seo, Sung Hee Lee
Oct 23, 2018·Gastroenterology Research and Practice·Patrick L StonerEllen M Zimmermann
Feb 23, 2019·Inflammatory Bowel Diseases·Tawnya M HansenYvette Leung
Jul 7, 2018·Therapeutic Advances in Gastroenterology·Paulo Gustavo KotzeAmy L Lightner
Mar 7, 2021·Journal of Clinical Medicine·Abel Botelho QuaresmaPaulo Gustavo Kotze

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