PMID: 9422574Jan 9, 1998Paper

Preoperative vs. postoperative radiation prophylaxis of heterotopic ossification: a rural community hospital's experience

International Journal of Radiation Oncology, Biology, Physics
D A Kantorowitz, N S Muff

Abstract

In vivo data employing a rat model, suggest equivalent suppression of ectopic bone formation by single-fraction irradiation given either pre (< or = 4 h)- or post (< or = 24 h)-surgery. Two subsequent randomized clinical trials, from tertiary academic centers with robust experience in heterotopic bone prophylaxis, have reached similar conclusions. To assess the transferability of the above data to the community setting we reviewed our rural community hospital experience with pre- and postoperative radiation prophylaxis. Between 11/90 and 6/96, 16 surgerized hips with high risk of heterotopic bone formation received 7.00-8.00 Gy in one fraction either preoperatively (< or = 4 h) (n = 9) or postoperatively (< or = 3 days for six hips; day 7 for one hip) (n = 7). Initial patients were routinely treated postoperatively. In late 1992, treatment preference was switched to preoperative irradiation in response to evolving data. The two groups were similar with respect to age, sex, nature of surgery, presurgical Brooker and Harris scores, and in U. of Rochester risk classification distribution. Irradiation was given via 4-20 MV photons through equally weighted AP:PA portals to the periacetabular tissues and proximal one third to one-hal...Continue Reading

References

Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·D A KantorowitzC R Ahrens
May 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A KonskiP Rubin
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·L H BlountR G Parker
Jan 1, 1984·International Journal of Radiation Oncology, Biology, Physics·I MacLennanP Rubin
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·M H SeegenschmiedtR Sauer

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Citations

Nov 8, 2001·International Journal of Radiation Oncology, Biology, Physics·M H SeegenschmiedtUNKNOWN German Cooperative Group on Radiotherapy for Benign Diseases
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M L HaasR G Slawson
Feb 27, 2010·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Ashley W JensenRobert L Foote
Aug 28, 2014·Plastic and Reconstructive Surgery·Michiel C E van LeeuwenFrank B Niessen
May 20, 1999·The Journal of Urology·G P Zagaja, W J Cromie
Feb 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael N WosczynaDavid J Goldhamer
Oct 19, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xuhui LiuBernard Halloran
Dec 14, 2018·International Orthopaedics·Jakob BollmannChristian Merle
Mar 27, 2019·Journal of Orthopaedic Surgery·Sebastian RuettenMartin Komp

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