Preoperatively diagnosed ductal carcinoma in situ: risk prediction of invasion and effects on axillary management

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Yuya SatoHitoshi Tsuda

Abstract

Preoperatively diagnosed ductal carcinoma in situ (DCIS) has the potential to have occult invasion. The predictors of invasive carcinoma underestimation in patients with DCIS diagnosed by preoperative percutaneous biopsy were identified and the effects of underestimation on axillary management were evaluated. Medical records of 280 patients preoperatively diagnosed as DCIS who underwent surgery were retrospectively analyzed. The patients were divided into non-invasive and invasive carcinoma groups according to the final pathological diagnosis. Risk predictors of invasive carcinoma underestimation and axillary lymph node (ALN) metastasis were analyzed. The axillary status estimated by pathological diagnosis and one-step nucleic acid amplification (OSNA) assay was evaluated. The presence of an invasive carcinoma was overlooked in 104 (37.1 %) patients. A clinically palpable mass was an independent risk predictor of invasive carcinoma underestimation by multivariate analysis. There was no risk predictor of ALN metastasis. No ALN metastasis was seen in non-invasive carcinoma group. Six (6.2 %) patients in invasive carcinoma group had macro- or micrometastasis in sentinel lymph nodes (SLNs). Non-SLN metastasis was observed in 3 pati...Continue Reading

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Citations

Mar 11, 2016·Annals of Surgical Oncology·Melissa PilewskieTari A King
Feb 15, 2018·Annals of Surgical Treatment and Research·Sungchul KimHayong Yum
May 27, 2020·Molecular and Clinical Oncology·Goshi OdaHiroyuki Uetake
Dec 15, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lea LowenfeldBrian J Czerniecki

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