Preoperatively molecular staging with CM10 ProteinChip and SELDI-TOF-MS for colorectal cancer patients

Journal of Zhejiang University. Science. B
Wen-hong XuSu-zhan Zhang

Abstract

To detect the serum proteomic patterns by using SELDI-TOF-MS (surface enhanced laser desorption/ ionization-time of flight-mass spectrometry) technology and CM10 ProteinChip in colorectal cancer (CRC) patients, and to evaluate the significance of the proteomic patterns in the tumour staging of colorectal cancer. SELDI-TOF-MS and CM10 ProteinChip were used to detect the serum proteomic patterns of 76 patients with colorectal cancer, among them, 10 Stage I, 19 Stage II, 16 Stage III and 31 Stage IV samples. Different stage models were developed and validated by support vector machines, discriminant analysis and time-sequence analysis. The Model I formed by 6 protein peaks (m/z: 2759.58, 2964.66, 2048.01, 4795.90, 4139.77 and 37761.60) could be used to distinguish local CRC patients (Stage I and Stage II) from regional CRC patients (Stage III) with an accuracy of 86.67% (39/45). The Model II formed by 3 protein peaks (m/z: 6885.30, 2058.32 and 8567.75) could be used to distinguish locoregional CRC patients (Stage I, Stage II and Stage III) from systematic CRC patients (Stage IV) with an accuracy of 75.00% (57/76). The Model III could distinguish Stage I from Stage II with an accuracy of 86.21% (25/29). The Model IV could distingui...Continue Reading

References

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Citations

Apr 26, 2011·International Urology and Nephrology·Minmin WangJianghua Chen
Jan 19, 2012·Gastroenterology Research and Practice·Nai-Jun FanXiu-Li Wang
May 5, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Gang SunFeifei Zhang
Oct 12, 2010·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hong HeYanqing Cong
Sep 8, 2009·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Hong HeFeiyun Ping
Oct 5, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Joseph S K AuStephen C K Law
Feb 13, 2008·Journal of Cellular and Molecular Medicine·L C WhelanW M Gallagher
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hong JiangZhi-Guo Zheng
Nov 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenhong XuYiding Chen
Mar 1, 2012·Journal of Zhejiang University. Science. B·Zhan-Huai WangSu-Zhan Zhang
Nov 7, 2008·Journal of Zhejiang University. Science. B·Hussain Montazery-KordyMohammad Hassan Moradi
Aug 4, 2006·American Journal of Physiology. Cell Physiology·Thuy D Vo, Bernhard O Palsson
Oct 31, 2014·World Journal of Gastroenterology : WJG·Xiao-Li JinYu-Lian Wu

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