Preovulatory luteinization during induction of follicular maturation with menotrophin and menotrophin--clomiphene combination

Human Reproduction
A BirkenfeldD Navot

Abstract

Late follicular phase levels of 17 beta-oestradiol (E2) and progesterone (P) in serum were studied during the induction of follicular maturation with human menopausal gonadotrophin (HMG) (n = 23) and HMG-clomiphene citrate (CC) (n = 18). For each patient one hormonal profile was studied between 6 days to 2 h before administration of human chorionic gonadotrophin (HCG). Ultrasonographic follicular measurement at the time of evaluation demonstrated preovoulatory ovarian follicles of various number and size in all patients studied. Sixteen endometrial biopsies were performed at the time of evaluation (eight for each subgroup), before HCG administration. Mean late follicular phase levels of E2 did not differ significantly between the two groups (436 +/- 348 and 475 +/- 267 pg/ml for the HMG and HMG-CC groups respectively). The mean progesterone levels in the HMG-CC group (1.233 +/- 0.67 ng/ml) was significantly higher than that for the HMG group of (0.86 +/- 0.55 ng/ml, P less than or equal to 0.04). The mean time interval between ovulation and HCG administration for the two groups was 2.5 and 2.4 days for the HMG and HMG-CC groups, respectively. In all eight biopsies taken from the HMG group, various stages of endometrial prolifer...Continue Reading

Citations

Jun 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·A Birkenfeld, D Navot
Sep 30, 1994·Annals of the New York Academy of Sciences·A Birkenfeld
Apr 20, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gian Mario TiboniFranca Giampietro

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