PMID: 6112160Feb 1, 1981Paper

Preparation and beta adrenolytic activity of some derivatives of naphthol-[2,1-b]furan

Il Farmaco; edizione scientifica
G GiovanninettiR Gaggi

Abstract

Some 1-(naphtho[2,1-b]furan-2-yl)-2-(t-butylamino)ethanols were synthesized for possible beta-adrenergic receptor blockade. The compounds may be considered to be derived from naphthyloxypropanolamines, the side chain of which is partially included in a furan ring. The pharmacological profile of 1-(naphtho[2,1-b]furan-2-yl)-2-(t-butylamine)ethanol (I b) is quite similar to that of propranolol without cardiac depressant properties.

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