Preparation and characterization of aminated hyaluronic acid/oxidized hydroxyethyl cellulose hydrogel

Carbohydrate Polymers
Pengfeng LuoMin Nie

Abstract

Hydrogel wound dressing is a new type of biomaterial with great absorbent capacity, which has been extensively researched and its application in the field of biomedicine is common. In this study, we prepared a novel composite hydrogel made of hyaluronic acid (HA) and hydroxyethyl cellulose (HEC), both of them are natural polysaccharides. Then, the structure and properties of this composite hydrogel were characterized and tested. The results gained from these studies show that this composite materials have a series of excellent performance such as appropriate gelation time, good swelling ability, suitable water evaporation rate, well hemocompatibility and biological compatibility. In particular, the super absorbent capacity (the maximum swelling rate is 2888%), which is conducive to maintain a moist wound healing environment. Taking account of these properties, this hydrogel can be used clinically as a wound dressing.

Citations

Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariana I NevesCristina C Barrias
Jul 23, 2020·Environmental Science and Pollution Research International·Najeh MaaloulMario Díaz
Apr 17, 2021·Journal of Biomaterials Science. Polymer Edition·Lingying WuXiangdong Kong
Jul 10, 2019·International Journal of Biological Macromolecules·Ashiq Hussain PanditSharif Ahmad
Jun 12, 2021·Colloids and Surfaces. B, Biointerfaces·Nandita SrivastavaAnirban Roy Choudhury
Dec 29, 2020·Chemical Reviews·Victoria G Muir, Jason A Burdick

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