Preparation and characterization of an injectable thermosensitive hydrogel for simultaneous delivery of paclitaxel and doxorubicin

Research in Pharmaceutical Sciences
Mahboubeh RezazadehJaber Emami

Abstract

In the current study, we aimed to develop a novel injectable thermosensitive hydrogel for simultaneous intra-tumoral administration of paclitaxel (PTX) and doxorubicin hydrochloride (DOX). At first, mixed micelles composed of Pluronic F127 and α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was loaded with PTX and their physicochemical properties including particle size, zeta potential, drug loading content, entrapment efficiency, and the drug release were investigated in details. In the second step, the optimized PTX-loaded micelles prepared in the first step were incorporated into the thermosensitive Pluronic F127/hyaluronic acid (PF127/HA) hydrogel containing fixed amount of DOX. Gel formation temperature, rheological properties, injectability, degradation rates of the hydrogel, and the release rate of PTX and DOX from the hydrogel were examined. The mean particle sizes and zeta potentials of the PTX-loaded micelles were 157.5 ± 20.1 nm and -9.6 ± 1.1 mV, respectively. The entrapment efficiency of the formulation was about 51%. The hydrogel containing PTX-loaded micelles and DOX existed as a solution with low viscosity at 4 °C converted to a semisolid upon increasing the temperature to 35 °C. DOX was completely releas...Continue Reading

References

Mar 12, 2005·The AAPS Journal·Anand Babu Dhanikula, Ramesh Panchagnula
Feb 18, 2011·The New England Journal of Medicine·Janet WoodcockRachel E Behrman

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Citations

Jan 8, 2020·Materials·Adam ChyzyMarta E Plonska-Brzezinska
Jul 17, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Shao-Bo BaiSi-Yuan Zhou
Apr 24, 2021·Drug Discovery Today·Ana C MarquesMaria H Amaral
Jan 31, 2019·Molecular Pharmaceutics·Fakhrossadat EmamiSimmyung Yook

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