Preparation and characterization of antibacterial magnetic-/pH-sensitive alginate/Ag/Fe3O4 hydrogel beads for controlled drug release.

International Journal of Biological Macromolecules
Bahaaldin RashidzadehShadi Abdi

Abstract

This work reports the synthesis of novel antibacterial magnetic-/pH-sensitive hydrogel beads based on ionotropic-gelation of alginate biopolymer. Using pomegranate peels extract, green-Ag nanoparticles were synthesized inside a mixture of alginate and Fe3O4, via in situ method. The alginate beads were investigated by VSM, TEM, XRD, and FE-SEM techniques. The introducing Ag and Fe3O4 nanoparticles in hydrogel beads caused a reduction in the swelling capacity of hydrogel beads. Besides, a pH-dependent swelling behavior was observed for hydrogel beads with a maximum swelling capacity at pH = 7.4. Diclofenac sodium (DS) as a model drug was loaded in hydrogel beads and its release showed a pH-dependent behavior. Drug release studies exhibited significant behaviors on the subject of physiological simulated pHs with a high release rate at pH = 7.4. The alginate beads have shown a prolonged and successive controlled drug release nearly 83% at pH = 7.4 and time 200 min. In addition to the pH, the release of DS from magnetic beads was affected by the external-magnetic-fields. Also, the Ag-incorporated alginate beads showed strong antibacterial activity against S. aureus and E. coli. These results indicated that the hydrogel beads have po...Continue Reading

Citations

Jan 14, 2021·Journal of Food Science·Khaing Zar MyintJie Shen
Apr 16, 2021·International Journal of Biological Macromolecules·Dong YangChaohua Xue
Apr 24, 2021·International Journal of Biological Macromolecules·Bianca G QueirozElisabete Frollini
May 11, 2021·Carbohydrate Polymers·Thalia S A LemosAndré R Fajardo
Jul 3, 2021·Pharmaceutics·Cassiele T CescoAlexandre T Paulino

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