Preparation and characterization of bioactive composite scaffolds from polycaprolactone nanofibers-chitosan-oxidized starch for bone regeneration

Carbohydrate Polymers
Jhamak NourmohammadiSamira Hosseini Liavali

Abstract

The objective of this study was to fabricate and investigate the characteristics of a suitable scaffold for bone regeneration. Therefore, chitosan was combined with various amounts of oxidized starch through reductive alkylation process. Afterwards, chopped CaP-coated PCL nanofibers were added into the chitosan-starch composite scaffolds in order to obtain bioactivity and mimic bone extracellular matrix structure. Scanning electron microscopy confirmed that all scaffolds had well-interconnected porous structure. The mean pore size, porosity, and water uptake of the composite scaffolds increased by incorporation of higher amounts of starch, while this trend was opposite for compressive modulus and strength. Osteoblast-like cells (MG63) culturing on the scaffolds demonstrated that higher starch content could improve cell viability. Moreover, the cells spread and anchored well on the scaffolds, on which the surface was covered with a monolayer of cells.

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Citations

Apr 21, 2017·Journal of Biomedical Materials Research. Part a·Phammela N Abarzúa-IllanesLoreto M Valenzuela
Aug 11, 2017·Materials·Sreejith RaveendranD Sakthi Kumar
Nov 9, 2019·Current Pharmaceutical Design·Tatiana Rita de Lima NascimentoLúcio Roberto Cançado Castellano
Jun 12, 2019·Journal of Biomaterials Science. Polymer Edition·Sugandha ChahalFathima Shahitha Jahir Hussian
May 11, 2021·International Journal of Biological Macromolecules·Farzad SeidiMasoud Mozafari

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