Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin

BioImpacts : BI
Ramanjot KaurInderbir Singh

Abstract

Introduction: Skin can be used as a site for local and systemic drug administration. Diffusion of drugs through the skin has led to the development of different transdermal drug delivery systems. Curcumin is a wound healing and anti-inflammatory agent. Curcumin was incorporated into biocomposite films of carrageenan (κC)/locust bean gum (LBG)/ montmorillonite (MMT) prepared by a solvent casting method. Methods: Film-forming solutions were prepared by adding and 2.5% v/v of propylene glycol and MMT (30% w/w). The curcumin loaded polymer composite transdermal films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. Mechanical properties in terms of tensile strength and extensibility were studied. Films were also evaluated for moisture content, moisture uptake, thickness, folding endurance, swelling ratio and water vapor transmission rate (WVTR). Results: κC and κC/L40 showed the highest percent cumulative release of 80.42±1.61% and 69.38±1.26% among all of the polymer composite transdermal films in 8 hours and 24 hours respectively. Conclusion: In vitro release profiles showed that increasing concentration of LBG and MM...Continue Reading

References

Dec 30, 2016·Future Science OA·Inderpreet Singh KhuranaRajneet Kaur Khurana

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Citations

Oct 22, 2020·Polymers·Zoi TerzopoulouDimitrios Bikiaris
Mar 17, 2020·International Journal of Biological Macromolecules·Bianca-Ioana DogaruMaria-Cristina Popescu

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