Preparation and characterization of catechin-grafted chitosan with antioxidant and antidiabetic potential

International Journal of Biological Macromolecules
Weili Zhu, Zhanjun Zhang

Abstract

In the present study, the preparation, characterization, antioxidant and antidiabetic activities of catechin-grafted chitosan (catechin-g-chitosan) were investigated. The graft of catechin onto chitosan was achieved by redox system and confirmed using various instrumental methods. Proton nuclear magnetic resonance spectroscopy indicates that catechin has been successfully grafted onto chitosan. The morphology observation shows that chitosan changes to a softened nature with porous surface after grafting. Catechin-g-chitosan also exhibits reduced thermal stability and enhanced crystallinity compared to chitosan. Moreover, catechin-g-chitosan shows 0.51 of reducing power, 46.81% of hydroxyl radical-scavenging activity and 67.08% of DPPH radical-scavenging activity at 1mg/ml, which are much higher than that of chitosan. The antidiabetic activity in vitro assays shows that the α-glucosidase inhibitory effect decreases in the order of catechin-g-chitosan>catechin>acarbose>chitosan, and the α-amylase inhibitory effect decreases in the order of acarbose>catechin-g-chitosan>catechin>chitosan. The improved antioxidant and antidiabetic activities of catechin-g-chitosan are attributed to the phenolic groups in the catechin residues.

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Citations

Jan 29, 2016·International Journal of Biological Macromolecules·Zihao Wei, Yanxiang Gao
Nov 22, 2015·International Journal of Biological Macromolecules·Jun LiuChang-Hai Jin
May 11, 2016·International Journal of Biological Macromolecules·Jun LiuChang-Hai Jin
Jul 31, 2016·Carbohydrate Polymers·Qiaobin Hu, Yangchao Luo
Oct 6, 2016·Carbohydrate Polymers·María Jesús Moreno-VásquezAbril Zoraida Graciano-Verdugo
Mar 27, 2020·International Journal of Molecular Sciences·Saikat DewanjeeVincenzo De Feo
Jun 16, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mohammad MoazeniAmir Mootabi Alavi
Dec 2, 2020·Antioxidants·Zvezdelina Yaneva, Donika Ivanova
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Jan 23, 2021·International Journal of Biological Macromolecules·Huixia HuJun Liu
Nov 23, 2020·Environmental Science and Pollution Research International·Ajay KumarSatwinderjeet Kaur
Apr 19, 2021·International Journal of Biological Macromolecules·Qingbin GuoChanglu Wang
Jul 24, 2021·Carbohydrate Polymers·Vinoth KrishnanMurugan Veerapandian
Aug 9, 2021·International Journal of Biological Macromolecules·Zhendong DingFansheng Kong
Aug 28, 2021·ACS Applied Materials & Interfaces·Jordan BritoSvetlana A Sukhishvili

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