PMID: 26328451Sep 4, 2015Paper

Preparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Delivery

Journal of Nanoscience and Nanotechnology
Mariana Da Silva BarbiMaria Palmira Daflon Gremião

Abstract

Zidovudine (AZT) is the antiretroviral drug most frequently used for the treatment of Acquired Immunodeficiency Syndrome. Its low oral bioavailability demands the development of innovative strategies to overcome the first pass metabolism. The nasal route is an option for enhanced therapeutic efficacy and to reduce the extent of the first-pass effect. In this article, AZT loaded chitosan nanoparticles were prepared by a modified ionotropic gelation method with sodium tripolyphosphate. The increase proportion of CS (NP1 10:01 (w/w)) promoted the formation of smaller nanoparticles (260 nm), while raising the proportion of TPP (NP2 5:1 w/w) increased the nanoparticles size (330 nm). The incorporation of AZT increased the nanoparticles size for both AZT-loaded nanoparticles AZT-loaded NP1 (406 nm) and AZT-loaded NP2 (425 nm). The incorporation of AZT into NP1 did not change the electrophoretic mobility, however, in AZT-loaded NP2 there was a significant increase. The positive surface of the nanoparticles is very important for the mucoadhesive properties due interaction with the sialic groups of the mucin. Nuclear resonance magnetic data showed that the higher concentration of chitosan in the nanoparticles favored the interaction of ...Continue Reading

Citations

Feb 16, 2016·Journal of Drug Targeting·Kevin B Ita
Apr 19, 2016·Expert Opinion on Drug Delivery·P RajithaR Jayakumar
Apr 21, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Aarti BelgamwarPramod Yeole
Apr 24, 2019·Journal of Cosmetic Dermatology·Dhidhin Raju, Jobin Jose
Apr 20, 2018·Current Drug Discovery Technologies·Rajalakshmi RukmangathenPrasanna Raju Yalavarthi
Sep 27, 2016·Expert Opinion on Drug Delivery·Chintan BhavsarAbdelwahab Omri
Feb 6, 2017·Biological & Pharmaceutical Bulletin·Akiko TanakaAkira Yamamoto
May 21, 2021·International Journal of Pharmaceutics·Natália N FerreiraMaria Palmira D Gremião
Jul 2, 2021·Photodiagnosis and Photodynamic Therapy·Carolina SanteziLívia Nordi Dovigo
Oct 15, 2020·Carbohydrate Polymers·Leonardo M B FerreiraMaria Palmira D Gremião

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