Preparation and characterization of complexes of liposomes with gold nanoparticles

Colloids and Surfaces. B, Biointerfaces
Chie KojimaKenji Kono

Abstract

Gold nanoparticles (Au NPs), which are extremely useful materials for imaging and photothermal therapy, typically require a drug delivery system to transport them to the affected tissue and into the cells. Since liposomes are approved as drug carriers, complexes of liposomes with Au NPs were considered ideal solutions to deliver Au NPs to the target site in vivo. In this study, we prepared complexes of various liposomes with Au NPs via physical absorption and characterized them. The time dependency of the surface plasmon resonance of this complex, which is a unique property of Au NPs, shows that the liposomes promote the formation of stable dispersions of Au NPs under isotonic conditions, even though intact Au NPs aggregate immediately. From a release assay of calcein from liposomes and transmission electron microscopy analysis, the Au NPs were complexed with liposomes without membrane disruption. These complexes could be formed by using cationic liposomes and polyethylene glycol-modified liposomes, as well as by using phosphatidylcholine liposomes, which are useful for drug and gene delivery. We proposed this kind of complex as a nanomedicine with diagnostic and therapeutic ability.

References

May 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaohong LiYongfang Li
Mar 8, 2006·Colloids and Surfaces. B, Biointerfaces·Sung-Hee ParkSung-Sik Han
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Citations

Aug 5, 2011·Accounts of Chemical Research·Wafa' T Al-Jamal, Kostas Kostarelos
Jun 9, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Yanjing Chen, Geoffrey D Bothun
Jan 31, 2013·Molecular Pharmaceutics·Aneta J MieszawskaDavid P Cormode
Sep 11, 2010·Chemical Communications : Chem Comm·Clara YagüeJesus Santamaria
Jan 8, 2011·Chemical & Pharmaceutical Bulletin·Myung Joo KangYoung Wook Choi
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Jun 15, 2011·Expert Opinion on Drug Delivery·Matthew R Preiss, Geoffrey D Bothun
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Feb 26, 2016·Angewandte Chemie·Kouta SugikawaAtsushi Ikeda
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Jun 26, 2012·Chemistry and Physics of Lipids·Dan QiuXingyuan Ma
Oct 13, 2016·Radiation Oncology Journal·Mi Sun KimWoong Sub Koom
Jun 7, 2014·Applied Biochemistry and Biotechnology·Mohanlal Bhuvana, Venkataraman Dharuman
Apr 5, 2021·Journal of Mass Spectrometry : JMS·Alberto OnzoGiuliana Bianco
Nov 20, 2016·International Journal of Pharmaceutics·Zahraa Al-AhmadyKostas Kostarelos
Jul 14, 2021·Pharmaceutical Research·Junye LiuNing Zhang
Sep 4, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Zahraa S Al-AhmadyKostas Kostarelos

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