PMID: 8593275Jan 31, 1996Paper

Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity

Biochimica Et Biophysica Acta
Jan A A M KampsG L Scherphof

Abstract

Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) that was earlier shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1), was covalently coupled to conventional liposomes, consisting of phosphatidylcholine, cholesterol and maleimido-4-(p-phenylbutyryl)phosphatidylethanolamine, using the heterobifunctional reagent N-succinimidyl-S-acetylthioacetate (SATA). The amount of HSA that could be coupled to the liposomes depended on derivatization of the HSA and ranged from 64.2 +/- microgram HSA/micromol total lipid for native HSA to 29.5 +/- 2.7 microgram HSA/micromol total lipid for HSA in which 53 of the epsilon amino groups of lysine were derivatized with cis-aconitic anhydride (Aco53-HSA). Incorporation of 3.8 mol% of total lipid of a poly(ethylene glycol) derivative of phosphatidylethanolamine (PEG-PE) in the liposomes resulted in a lower coupling efficiency of Aco-HSA. The elimination and distribution of the liposomal conjugates in rats in vivo was largely dependent on the modification of the HSA coupled to the liposomes. With native HSA-liposomes, more than 70% of the conjugate was still found in the blood plasma 30 min after i.v. injection in rats, while at this time Aco-HSA-lipos...Continue Reading

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Citations

Oct 13, 2007·Pharmaceutical Research·Sean M HartigJeffrey M Davidson
Sep 1, 2000·Advanced Drug Delivery Reviews·S P Vyas, V Sihorkar
Jun 6, 2000·Advanced Drug Delivery Reviews·J A Kamps, G L Scherphof
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·J A KampsG L Scherphof
Jan 7, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Piotr S KowalskiJan A A M Kamps
Apr 1, 2015·Chemistry and Physics of Lipids·Christophe SaloméLine Bourel-Bonnet
Dec 3, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Piotr S KowalskiJan A A M Kamps
Jan 27, 2005·Biochemical and Biophysical Research Communications·Xuedong YanJan A A M Kamps
Aug 19, 2000·Antiviral Chemistry & Chemotherapy·M Lüscher-Mattli
Apr 4, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohamed GaberAhmed Elzoghby
Apr 27, 1999·FEBS Letters·E L RomeroG L Scherphof
Jul 9, 2017·Journal of the American Society of Nephrology : JASN·Mira ChoiRalph Kettritz
Sep 15, 2005·Chemistry : a European Journal·Antoine Richard, Line Bourel-Bonnet
Oct 13, 1998·Journal of Drug Targeting·A Désormeaux, M G Bergeron
Feb 23, 2007·The Journal of Pharmacology and Experimental Therapeutics·Joanna E AdrianJan A A M Kamps
Jun 7, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yu ZhangGuizhi Zhu
Mar 20, 2019·Pharmaceutics·Ada W Y LeungMarcel B Bally
Dec 28, 2007·American Journal of Physiology. Renal Physiology·Sigrídur A AsgeirsdóttirJan A A M Kamps
Oct 31, 2007·Journal of Drug Targeting·Alida H Weeke-KlimpJan A A M Kamps
Aug 14, 1997·Biochimica Et Biophysica Acta·L R BarclayM R Vinqvist

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