Preparation and characterization of gelatin-bioactive glass ceramic scaffolds for bone tissue engineering

Journal of Biomaterials Science. Polymer Edition
Ashley Thomas, Japes Bera

Abstract

Macroporous composite scaffolds comprising of gelatin and glass ceramic has been fabricated and characterized for bone tissue engineering applications. Gelatin scaffold with varying glass-ceramic content was fabricated using lyophilization technique. The microstructure, compressive strength, bioactivity, biodegradation and biocompatibility of the fabricated scaffolds were evaluated. The scaffolds presented macroporous pore size with porosity varying from 79 to 84%. The compressive strength was enhanced by glass ceramic addition and the scaffolds exhibited strength in the range of 1.9 to 5.7 MPa. The obtained strength and porosity was in the range of cancellous bone. The dissolution of gelatin scaffolds was optimized by an additional in situ glutaraldehyde crosslinking step and further by glass-ceramic addition. The composite scaffolds showed good apatite-forming ability in vitro. Biocompatibility and osteogenic ability of the scaffolds were analyzed in vitro by cell adhesion study, alkaline phosphatase activity and Alizarin S staining. The obtained results revealed the composite scaffolds possessed enhanced osteogenic ability and good cell adhesion properties. The developed scaffold is a prospective candidate as a biomaterial f...Continue Reading

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Citations

Mar 19, 2021·Journal of Biomedical Materials Research. Part a·Angela Maria Paiva MagriAna Claudia Muniz Rennó
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dokyeong KimMyung-Jin Lee
Nov 14, 2020·International Journal of Biological Macromolecules·Mozhgan Keshavarz, Parvin Alizadeh
Nov 20, 2021·ACS Biomaterials Science & Engineering·Marjan BahraminasabMohammad Sadegh Nourbakhsh

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Methods Mentioned

BETA
confocal microscopy

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