Preparation and characterization of gelatin sponge millispheres from air-in-water-in-oil-type emulsions.

Journal of Materials Science. Materials in Medicine
Noboru YamashitaAtsushi Maruyama

Abstract

A novel method for the preparation of gelatin sponge millispheres (GSMs) for biomaterials such as embolic agents and cell scaffolds was developed using an air-in-water-in-oil-type emulsion. The droplets, consisting of a foamy gelatin suspension in caprylic triglyceride, were gelled and rinsed with isopropanol. Sonication and depressurization were used during the rinsing process to create interconnected pores. GSMs cross-links created over 4 h at 155 degrees C without any agent were insoluble and had short and long diameters of 1.1 +/- 0.2 mm and 1.3 +/- 0.2 mm, respectively. The residual isopropanol and caprylic triglyceride were <0.05% (w/w) and <1% (w/w) respectively. The level of bacterial endotoxins in the extracts was below 0.025 EU/ml, and no bacterial or fungal growth was found during sterility testing. The GSMs produced using this method were considered to meet the basic requirements of embolic agents.

References

Jun 1, 1990·Cardiovascular and Interventional Radiology·R YamadaM Satoh
Jan 1, 1969·Progress in Experimental Tumor Research·G Bryson, F Bischoff
Jul 1, 1994·Journal of Pharmaceutical Sciences·G A DigenisV P Shah
Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A TraulD Nakhasi
Jan 5, 2002·AJR. American Journal of Roentgenology·Tetsuya KatsumoriMitsukuni Tokuhiro
Jan 10, 2003·Journal of Biomaterials Science. Polymer Edition·Kezban UlubayramNesrin Hasirci
Feb 14, 2004·Journal of Vascular and Interventional Radiology : JVIR·Karen T Brown
Oct 28, 2004·Gastroenterology·Jordi BruixJosep M Llovet
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Jul 16, 2005·Biomaterials·Maud B Gorbet, Michael V Sefton
Mar 29, 2006·Journal of Pharmacological and Toxicological Methods·Sabine PestelBrian Guth
Sep 13, 2006·Cardiovascular and Interventional Radiology·Tetsuya Katsumori, Toshiyuki Kasahara

❮ Previous
Next ❯

Citations

Jan 1, 2009·Medical Devices : Evidence and Research·Noboru YamashitaAtsushi Maruyama
Oct 29, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Rita GelliMassimo Bonini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved