PMID: 9429100Jan 16, 1998Paper

Preparation and characterization of heparin-containing SBS-g-DMAEMA copolymer membrane

Journal of Biomedical Materials Research
J M YangC H Chang

Abstract

The grafting of dimethyl amino ethyl methacrylate (DMAEMA) onto styrene-butadiene-styrene triblock copolymer (SBS) membrane was subsequently conducted by UV-radiation induced graft copolymerization without degassing to obtain the SBS-g-DMAEMA copolymer membrane. The substituted amino groups on the SBS-g-DMAEMA graft copolymer membrane were quaternized with iodomethane, and then the membrane was treated with heparin to prepare the heparin-containing SBS-g-DMAEMA copolymer membrane (SBS-g-DMAEMA-HEP). The graft copolymer membrane (SBS-g-DMAEMA) and the heparin-containing SBS-g-DMAEMA copolymer membrane (SBS-g-DMAEMA-HEP) were characterized by FTIR spectroscopy. The heparin content was determined by toluidine blue heparin assay. Contact angle, water content, and protein adsorption of fibrinogen and albumin experiments were also performed to evaluate the effect of graft amount and heparin content on the biocompatibility of SBS-g-DMAEMA and SBS-g-DMAEMA-HEP graft copolymer membranes. By using Kaelble's equation, the surface tension of SBS-g-DMAEMA and SBS-g-DMAEMA-HEP were determined. It was found that with increasing grafting amount and the heparin content, the surface tension and water content of SBS-g-DMAEMA membrane increased, w...Continue Reading

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Citations

Jan 17, 2002·Biomaterials·Jai Paul Singhal, Alok R Ray
Jul 27, 2001·Journal of Biomaterials Science. Polymer Edition·G C XuK Awazu
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Yu-Chang TyanChia-Chieh Chen
May 2, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jen Ming YangJan Kan Chen
Aug 15, 2020·Regenerative Biomaterials·Pan ZhaoJun Fan
Dec 11, 2007·Soft Matter·Debashish RoySébastien Perrier

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