Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers

Chemical & Pharmaceutical Bulletin
T UchidaK Matsuyama

Abstract

The objectives of this study were to prepare insulin-loaded acrylic hydrogel formulations containing various absorption enhancers, to perform in vitro and in vivo characterization of these formulations, and to evaluate the factors which affecting insulin availability on rectal delivery of insulin using this hydrogel system. The acrylic block copolymer of methacrylic acid and methacrylate, Eudispert, was used to make the hydrogel formulations. As absorption enhancers, 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD), lauric acid (C12), or the sodium salt of C12 (C12Na), were incorporated into the hydrogels. In an in vitro release test, the release rate of insulin from the hydrogels decreased as the polymer concentration of the hydrogel increased. The addition of C12Na to the hydrogel further increased the insulin release rate, which was greater at higher concentrations of the enhancer. A portion of the C12Na was found to remain bound to the acrylic polymer in dissolution medium. Serum insulin levels were determined at various time points after the administration of insulin solution or insulin-loaded (50 units/kg body weight) Eudispert hydrogels containing 5% (w/w) of C12, C12Na, or DM-beta-CyD to in situ loops in various regions ...Continue Reading

References

Jun 11, 1999·International Journal of Pharmaceutics·R M Brand, F G Hamel
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Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·I Gliko-KabirA Rubinstein
Nov 22, 2000·Chemical & Pharmaceutical Bulletin·T UchidaK Matsuyama

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Citations

Nov 9, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Asako NishimuraNobuhito Shibata
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mariko MorishitaAnthony M Lowman
Jan 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kishore B ChalasaniSanjay K Jain
Aug 21, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kishore B ChalasaniSanjay K Jain
Jun 21, 2016·Advanced Drug Delivery Reviews·Sam MaherDavid J Brayden
Apr 18, 2009·Current Opinion in HIV and AIDS·Joseph RomanoPaulina E Kaptur
Oct 27, 2015·Journal of Nanobiotechnology·Garima SharmaChiranjib Chakraborty

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