Preparation and characterization of low dispersity anionic multiresponsive core-shell polymer nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
J P PinheiroJ P S Farinha

Abstract

We prepared anionic multistimuli responsive core-shell polymer nanoparticles with very low size dispersity. By using either acrylic acid (AA) or methacrylic acid (MA) as a comonomer in the poly(N-isopropyl acrylamide) (PNIPAM) shell, we are able to change the distribution of negative charges in the nanoparticle shell. The particle size, volume phase transition temperature, and aggregation state can be modulated using temperature, pH, or ionic strength, providing a very versatile platform for applications in sensors, medical diagnostics, environmental remediation, etc. The nanoparticles have a glassy poly(methyl methacrylate) (PMMA) core of ca. 40 nm radius and a cross-linked PNIPAM anionic shell with either AA or MA comonomers. The particles, p(N-AA) and p(MA-N), respectively, have the same total charge but different charge distributions. While the p(MA-N) particles have the negative charges preferentially distributed toward the inner shell, in the case of the p(N-AA) particles the charge extends more to the particle outer shell. The volume phase transition temperature (T(VPT)) of the particles is affected by the charge distribution and can be fine-tuned by controlling the electrostatic repulsion on the particle shell (using pH...Continue Reading

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Citations

Jun 19, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Jianying WangJintao Zhu
Nov 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Larisa V SigolaevaWalter Richtering
Feb 20, 2013·Biotechnology Journal·Luís BorlidoJosé Paulo S Farinha
Apr 4, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jennifer R S MartinJérôme F L Duval
Nov 15, 2016·Physical Chemistry Chemical Physics : PCCP·Elise RotureauJérôme F L Duval
May 4, 2017·Analytical Chemistry·Larisa V SigolaevaWalter Richtering
Feb 20, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Prof Alexander YaroslavovProf Fredric Menger
Jul 6, 2014·Journal of Applied Physiology·Eric R CastilloDaniel E Lieberman
Oct 8, 2019·Soft Matter·Giovanni Del MonteEmanuela Zaccarelli
Nov 19, 2019·Macromolecular Rapid Communications·Sarah K WypysekWalter Richtering
Nov 4, 2017·Polymers·Tânia RibeiroJose Paulo Farinha
Oct 4, 2019·Nanoscale·Helena RaabovaPetr Cigler
May 7, 2016·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Zi-Quan Cao, Guo-Jie Wang
May 28, 2020·Biomacromolecules·Victoria K SwitaczWalter Richtering
Jun 3, 2021·Pharmaceutics·José L M GonçalvesJosé Paulo S Farinha

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