Preparation and characterization of monodisperse molecularly imprinted polymer microspheres by precipitation polymerization for kaempferol

Designed Monomers and Polymers
Qiang XiaZhixia Liang

Abstract

A new kind of molecularly imprinted polymer (MIP) microspheres for the selective extraction of kaempferol was prepared by precipitation polymerization using 4-vinylpridine (4-VP) and ethylene glycol dimethacrylate (EDMA) as functional monomer and cross-linker respectively. The synthesis conditions, such as ratios of 4-VP/EDMA and polymerization time were discussed in detail. Results showed that the 2% was the optimal concentration of co-monomers to obtain monodisperse MIP microspheres, the best ratio of 4-VP/EDMA was 1:2, and 24 h was considered as the proper polymerization time. Compared with the MIP agglomeration or coagulum particles, monodisperse MIP microspheres showed the better adsorption capacity: the saturated adsorption capacity of monodisperse MIP microspheres was 7.47 mg g-1, the adsorption equilibrium could be obtained in 30 min. Finally, the adsorption performances of the optimal MIP microspheres were evaluated by kinetic adsorption, adsorption isotherm, and selective adsorption experiments, which indicated that the adsorption mechanism were chemical single layer adsorption and the separation factor was up to 3.91 by comparing with the structure similar compound (quercetin). The MIP microspheres exhibit prospects ...Continue Reading

References

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Citations

Jul 20, 2019·Journal of Environmental Health Science & Engineering·Omid Reza HeravizadehSeyed Jamaleddin Shahtaheri
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tirza Ecclesia OrowitzAliya Nur Hasanah
Nov 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·K Fremielle Lim, Clovia I Holdsworth

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Methods Mentioned

BETA
scanning electron microscopy

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