Preparation and characterization of niosomes containing rifampicin for lung targeting

Journal of Microencapsulation
C P Jain, S P Vyas

Abstract

Niosomes (non-ionic, surfactant-based vesicles) containing rifampicin of 8-15 microns in diameter were prepared using Span-85 and cholesterol in various molar fractions. The process variables that could affect the physical characteristics of niosomes and in vitro release of the drug from the niosomes were studied and optimized. In vivo distribution studies of the prepared niosomes found that 65% of the drug could be localized in the lungs by controlling the niosome size.

References

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Citations

Dec 31, 2003·International Journal of Pharmaceutics·S P VyasParamjit Singh
Jul 9, 2002·International Journal of Pharmaceutics·Tejas R Desai, Warren H Finlay
Sep 3, 2002·International Journal of Pharmaceutics·Yongmei HaoKe'an Li
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Apr 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Indu Pal Kaur, Harinder Singh
Jul 15, 2015·Journal of Drug Targeting·Smita Pawar, Pradeep Vavia
Mar 23, 2011·Drug Development and Industrial Pharmacy·Mohammed Shafik El-RidySameh Hosam Abd El-Alim
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May 19, 2017·AAPS PharmSciTech·Al-Zahraa M Khalifa, Bazigha K Abdul Rasool
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Feb 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Catherine T LoWyatt N Vreeland
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Xue JinShui Yu

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