Preparation and characterization of novel electrospun poly(ϵ-caprolactone)-based nanofibrous scaffolds

Artificial Cells, Nanomedicine, and Biotechnology
Alireza ValizadehSoodabeh Davaran

Abstract

Nanofibrous scaffolds have many advantages that make them excellent candidates for tissue engineering applications. The scaffolds with high surface area to volume ratio favor cell adhesion, proliferation, migration and differentiation. In the present study, the preparation of electrospun poly (ϵ-caprolactone)-polyethylene glycol-poly (ϵ-caprolactone) (PCL-PEG-PCL) nanofibers is shown for the first time. PCL-PEG-PCL copolymers were synthesized using a ring-opening polymerization method. The polymers were characterized by FT-IR, (1)H NMR and DSC. Nanofibers with mean diameters ranging from 60 to 170 nm were obtained by the electrospinning method. Their morphology was evaluated by scanning electron microscopy (SEM). An MTT assay was used to compare the number of cells in the nanofiber scaffold. It was found that the morphology and diameter of the nanofiber depended on the chemical composition and molecular weight of the PEG segment of the copolymer used for electrospinning. Increasing the molecular weight of PEG blocks from 2000 to 6000 led to a decrease of the diameter of the fibers and the formation of beads.

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Citations

Apr 5, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Mengyue GanHongwan Dang
May 18, 2016·Artificial Cells, Nanomedicine, and Biotechnology·S Sh Zargarian, V Haddadi-Asl
Jul 12, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mehdi DadashpourMohammad Nouri
Jul 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Azizeh Rahmani Del BakhshayeshAzadeh Montaseri
Jul 15, 2017·Journal of Biomaterials Science. Polymer Edition·Vahideh Raeisdasteh HokmabadRoya Salehi
Jul 27, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Nahideh AsadiAbolfazl Akbarzadeh
Feb 15, 2019·Tissue Engineering. Part a·Juliana A PassipieriGeorge J Christ
Aug 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Mahdieh AlipourVahideh Raeisdasteh Hokmabad
Jan 29, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Alireza ValizadehFariba Badrzadeh
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·M M Machado-PaulaA O Lobo

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