Preparation and characterization of silybin-loaded nanostructured lipid carriers

Drug Delivery
Lejiao JiaQiang Zhang

Abstract

Nanostructured lipid carriers (NLC) are a new generation of lipid nanoparticles, which are produced by controlled mixing of solid lipids with spatially incompatible liquid lipids leading to special nanostructures with improved drug incorporation and release properties. In this study, silybin-loaded nanostructured lipid carriers with various liquid lipid content were successfully prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The size and morphology of nanoparticles were significantly influenced by the liquid lipid content. As the liquid lipid content increased to 20 wt%, the obtained particles showed distinguished smaller size. Compared with solid lipid nanoparticles (SLN), NLC presented improved drug loading capacity which increased with increasing the liquid lipid content. The differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis indicated that the incorporation of liquid lipids could interfere with the crystallization of solid lipids. The drug in vitro release behavior from NLC displayed a biphasic drug release pattern with burst release at the initial stage and prolonged release afterwards, and the successful controlled release rate can be...Continue Reading

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Citations

Jun 3, 2011·World Journal of Gastroenterology : WJG·Carmela Loguercio, Davide Festi
Oct 12, 2013·Drug Delivery·Qiang WangWeidong Chen
Apr 22, 2011·Cancer Letters·Dandan ZhengQiang Zhang
Oct 27, 2015·International Journal of Pharmaceutics·Noha S El-SalamouniSafaa S El-Gamal
Nov 15, 2013·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Shubham UpritAniruddha Pare
Dec 30, 2014·International Journal of Pharmaceutics·Abhay Y KyadarkunteVarsha B Pokharkar
Aug 2, 2016·Advanced Pharmaceutical Bulletin·Leila Azhar Shekoufeh Bahari, Hamed Hamishehkar
Jan 20, 2017·Advanced Pharmaceutical Bulletin·Lavin AliasgharlouHamed Hamishehkar
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Di Costanzo, Ruggero Angelico
Jun 25, 2019·Current Medicinal Chemistry·Bruno Fonseca-SantosMarlus Chorilli
Nov 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo Kyeong YoonJoshua A Jackman
Apr 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chinazom Precious AgboKenneth Chibuzor Ofokansi

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