Preparation and characterization of solid lipid nanoparticle-based nasal spray of budesonide

Drug Delivery and Translational Research
Sandip S ChavanPradeep Vavia

Abstract

The present research work was aimed at developing solid lipid nanoparticle (SLN)-based formulation of budesonide (BDS) for nasal delivery. Melt emulsification method was chosen for fabrication of BDS-SLN using ultrasound dispersion and hot high-pressure homogenization techniques. The Compritol888 ATO was chosen as the lipid component for SLN formulation due to highest solubility for BDS. Different surfactants were screened and it was found that combination of Tween 80 and plurol oleique has shown desired particle size with improved stability and entrapment efficiency. The optimized SLN composition had a particle size of 185.2 nm with polydispersibility index of 0.387. Entrapment efficiency of the SLN composition was observed to be 61 %. Further, the optimized SLN dispersion was formulated into nasal spray. In vitro permeation study was carried out using Ovis aries (Indian sheep) nasal mucosa and it was observed that the permeability of BDS nasal spray of SLN was increased significantly by 3.4-fold as compared to the plain BDS and 1.8-fold as compared to the marketed nasal formulation. Thus, SLN-based nasal drug delivery was observed to be a promising approach for improving the bioavailability of hydrophobic drugs.

References

Jan 1, 1987·European Journal of Clinical Pharmacology·S PedersenO Borgå
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A zur MühlenW Mehnert
May 9, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·V JenningS H Gohla
Jun 6, 2000·Advanced Drug Delivery Reviews·L Pereswetoff-Morath
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Jan 29, 2002·Journal of Microencapsulation·V JenningS H Gohla
Apr 25, 2003·International Journal of Pharmaceutics·Michele TrottaOtto Caputo
Jul 3, 2003·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sylvia A Wissing, Rainer H Müller
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Dec 19, 2003·Journal of Clinical Pharmacology·Walter K KraftScott A Waldman
May 26, 2004·International Journal of Pharmaceutics·E B SoutoR H Müller
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·C PregoM J Alonso
Sep 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Catherine CharcossetHatem Fessi
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Huabing ChenXiangliang Yang
Sep 19, 2006·International Journal of Pharmaceutics·Jie LiuXiangliang Yang
Jun 22, 2007·The American Journal of Gastroenterology·Pardeep BrarPeter H R Green
Jul 22, 2008·Bone Marrow Transplantation·H AndreeD Wolff
Mar 11, 2010·Handbook of Experimental Pharmacology·Eliana B Souto, Rainer H Müller
May 27, 2010·Indian Journal of Pharmaceutical Sciences·S MukherjeeR S Thakur
Dec 15, 2011·AAPS PharmSciTech·Ketan PatelMangal Nagarsenker

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Citations

Sep 10, 2014·Journal of Liposome Research·Preeti R Wavikar, Pradeep R Vavia
Aug 28, 2019·Current Medicinal Chemistry·Areen AlshweiatIIdikó Csoka
Apr 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brett A DuguayMarianna Kulka

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