Preparation and characterization of surface-modified PLGA-polymeric nanoparticles used to target treatment of intestinal cancer

Artificial Cells, Nanomedicine, and Biotechnology
Niyaz AhmadFarhan J Ahmad

Abstract

Docetaxel (DTX), a cytotoxic taxane, is a poor water-soluble drug and exhibits less oral bioavailability. Current research investigates the effective transport, for DTX-loaded chitosan (CS)-coated-poly-lactide-co-glycolide (PLGA)-nanoparticles (NPs) (DTX-CS-PLGA-NPs) and DTX-PLGA-NPs as well as a novel third-generation P-gp inhibitor i.e. GF120918 (Elacridar), across intestinal epithelium with its successive uptake by the tumour cells in an in vitro model. The prepared NPs showed a spherical shape particle size i.e. <123.96 nm with polydispersity index (PDI) of <0.290 whereas for CS-coated NPs, the zeta potential was converted from negative to positive value along with a small modification in particle size distribution. The entrapment efficiency observed for DTX-CS-PLGA-NPs was 74.77%, whereas the in vitro release profile revealed an initial rapid DTX release followed by a sustained release pattern. For apparent permeability, DTX-CS-PLGA-NPs and DTX-PLGA-NPs along with GF120918 showed a five-fold (p < .01) and 2.2-fold enhancement, respectively, as observed in rat ileum permeation study. Similarly, for pharmacokinetic (PK) studies, higher oral bioavailability was observed from DTX-CS-PLGA-NPs (5.11-folds) and DTX-PLGA-NPs (3.29...Continue Reading

References

Apr 13, 1995·The New England Journal of Medicine·E K Rowinsky, R C Donehower
Mar 31, 1999·Bioorganic & Medicinal Chemistry Letters·M RoeP Charlton
Aug 25, 2000·Investigational New Drugs·L van ZuylenJ Verweij
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M M MalingréJ H Schellens
Apr 25, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Hilary Thomas, Helen M Coley
Sep 2, 2003·Pharmaceutical Research·Matthew D Troutman, Dhiren R Thakker
Jan 25, 2005·International Journal of Pharmaceutics·Rubiana M Mainardes, Raul C Evangelista
Mar 2, 2005·Nature Reviews. Cancer·Mauro Ferrari
Mar 21, 2006·European Journal of Medicinal Chemistry·L-P RuanS X Qiu
Aug 5, 2006·International Journal of Pharmaceutics·T MusumeciG Puglisi
Mar 6, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ryotaro KuniiYoshiharu Machida
Mar 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·G MittalM N V Ravi Kumar
Apr 19, 2007·Annual Review of Biomedical Engineering·Shuming NieJonathan W Simons
Sep 20, 2007·Journal of Pharmaceutical Sciences·Weilun KeYuanying Pei
Jan 16, 2009·Basic & Clinical Pharmacology & Toxicology·Henrik GréenCurt Peterson
Aug 28, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong-Mei YinDae-Duk Kim
Nov 4, 2010·Journal of Colloid and Interface Science·Zhimei SongGuangxi Zhai
Aug 9, 2012·Molecular Pharmaceutics·Sanyog JainAshish K Agrawal
Jan 8, 2013·Journal of Pharmaceutical Sciences·Mohammed Mostafa IbrahimMonica M Jablonski
May 9, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Garima JoshiKrutika Sawant
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Nenad IgnjatovićDragan Uskoković
Jun 7, 2016·International Journal of Biological Macromolecules·Niyaz AhmadFarhan Jalees Ahmad
Aug 2, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Erea BorrajoAnxo Vidal

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Citations

Mar 27, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ishwor PoudelC Bothiraja
Oct 9, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Mohammed SedkiIbrahim M El-Sherbiny
Feb 2, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Hafiz Shoaib SarwarGul Shahnaz
Sep 10, 2019·Therapeutic Delivery·Vahid Taghipour-SabzevarMehrdad Moosazadeh Moghaddam
Apr 14, 2020·Expert Opinion on Drug Delivery·Shahin AghamiriHossein Ghanbarian
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jiayuan ShenJun He
Dec 11, 2020·Nano Convergence·Julia SalapaJoseph Irudayaraj
Feb 16, 2021·Pharmaceutical Development and Technology·Marwa Hassan Shukr, Omar A Ahmed Farid
Mar 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Delaram BabadiAzadeh Haeri

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