PMID: 9655524Jul 9, 1998Paper

Preparation and EPR studies of lithium phthalocyanine radical as an oxymetric probe

Free Radical Biology & Medicine
M AfeworkiMurali C Krishna

Abstract

The electron paramagnetic resonance (EPR) spectrum of the paramagnetic center in solid lithium phthalocyanine, LiPc, exhibits a pO2 (partial pressure of oxygen)-dependent line width. The compound is insoluble in water and is not easily biodegradable and, therefore, is a useful spin probe for quantitative in vivo oxymetry. Because EPR spectrometry is potentially a useful technique to quantitatively obtain in vivo tissue pO2, such probes can be used to obtain physiological information. In this paper, a simple experimental procedure for the preparation of LiPc using potentiostatic electrochemical methods is described. The setup was relatively inexpensive and easy to implement. A constant potential ranging from 0.05 to 0.75 V versus Ag+/AgCl(s) was used for obtaining LiPc. The EPR spectral studies were carried out using spectrometers operating at X-band and at radiofrequency (RF) at different pO2 values to characterize the spectral response of these crystals. The results indicate that, depending on the electrolysis conditions, the products contain mixtures of crystals exhibiting pO2-sensitive and pO2-insensitive line widths. Electrolysis conditions are reported whereby the pO2-sensitive LiPc crystals were the predominant product. T...Continue Reading

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Citations

Oct 24, 2003·Free Radical Biology & Medicine·Ramasamy P PandianPeriannan Kuppusamy
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Mar 29, 2007·The Journal of Physical Chemistry. B·Joe Z SostaricPeriannan Kuppusamy
Jun 9, 2009·Chemical Communications : Chem Comm·Maya InagawaKunio Awaga
Jan 10, 2012·Chemical & Pharmaceutical Bulletin·Keizo TakeshitaShoko Okazaki
Jan 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shingo MatsumotoMurali C Krishna
Aug 25, 2004·Journal of Magnetic Resonance·Govindasamy IlangovanPeriannan Kuppusamy
Nov 1, 2005·Journal of Magnetic Resonance·Galina Diakova, Robert G Bryant
Nov 9, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Atsuko MatsumotoKen-Ichiro Matsumoto
Apr 24, 2016·Biomedical Microdevices·Vidya P BhallamudiRamasamy P Pandian
Jun 10, 2008·Journal of Magnetic Resonance·Subhojit SomPeriannan Kuppusamy
Oct 14, 2000·Annual Review of Physical Chemistry·J H Freed
Nov 20, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David CristeaAharon Blank
Dec 24, 2018·Journal of Magnetic Resonance·Randall PursleyNallathamby Devasahayam

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