Preparation and evaluation of controlled release microparticles for respiratory protein therapy

Journal of Pharmaceutical Sciences
Rania O SalamaPaul M Young

Abstract

A series of microparticle formulations, designed for controlled release pulmonary therapy, were evaluated in terms of their physical properties, aerosol performance, lung epithelial cell toxicity, and controlled release profile. A protein, bovine serum albumin (BSA) was chosen as a model macromolecule active ingredient which was coprocessed, using spray drying, with varying concentrations of the release modifier, polyvinyl alcohol (PVA). The spray dried microparticles were tested for their physico-chemical characteristics (e.g., size distribution, morphology and density), in vitro aerosolisation performance using a 5-stage Marple Miller Impactor (MMI) and in vitro release profiles by a custom-built diffusion cell (in 100 mL phosphate buffer pH 7.4). The toxicity of PVA on lung epithelial cells was investigated using a human alveolar basal epithelium A549 cell line. Analysis of the particle size data indicated that all the spray dried BSA/PVA samples had similar size distributions with a median particle diameter (d(0.5)) across all samples of 2.79 +/- 0.11 microm. All formulations had relatively good aerosolisation performance when compared to conventional dry powder inhalation (DPI) formulations although increasing PVA percenta...Continue Reading

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Citations

May 27, 2011·Pharmaceutical Research·Hui Xin OngPaul Michael Young
Apr 25, 2013·International Journal of Pharmaceutics·Aparna SaigalSui Yung Chan
Jul 17, 2012·AAPS PharmSciTech·Trevor RileySvetlana Lyapustina
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Apr 23, 2019·Journal of Pharmaceutical Sciences·Arianna FallacaraDaniela Traini
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