Preparation and evaluation of gelatin/sodium carboxymethyl cellulose polyelectrolyte complex microparticles for controlled delivery of isoniazid.

AAPS PharmSciTech
Nirmala Devi, Tarun K Maji

Abstract

The ratio of gelatin to sodium carboxymethyl cellulose (SCMC) at which maximum yield was obtained was optimized. This optimized ratio of gelatin to SCMC along with other parameters was used to prepare microparticles of different sizes. Vegetable oil was used as emulsion medium. Effect of various factors like amount of surfactant, concentration of polymer on the formation, and size of the microparticles was investigated. These microparticles were used as carrier for isoniazid. Among different cross-linkers, glutaraldehyde was found to be the most effective cross-linker at the temperature and pH at which the reaction was carried out. The loading efficiency and release behavior of loaded microparticles were found to be dependent on the amount of cross-linker used, concentration of drug, and time of immersion. Maximum drug loading efficiency was observed at higher immersion time. The release rate of isoniazid was more at higher pH compared to that of at lower pH. The sizes of the microparticles were investigated by scanning electron microscope. In all the cases, the microparticles formed were found spherical in shape except to those at low stirring speed where they were agglomerated. Fourier transform infrared study indicated the s...Continue Reading

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Citations

Sep 21, 2012·Journal of Microencapsulation·Hugo Costa, Ana Grenha
Aug 5, 2014·Journal of Microencapsulation·Chinmayee SaikiaTarun K Maji
Jan 5, 2016·Chemical & Pharmaceutical Bulletin·Lixia WangWuwei Wang
Sep 27, 2014·Carbohydrate Polymers·Ahmed Salama, Mohamed El-Sakhawy
Apr 18, 2016·International Journal of Biological Macromolecules·Ahmed SalamaSamir Kamel
Jun 15, 2016·Advances in Colloid and Interface Science·Nirmala DeviTarun K Maji
Sep 21, 2016·Pharmaceutical Development and Technology·Rongli LiJing Han
Aug 30, 2018·Macromolecular Bioscience·Andrea García-LizarribarJavier Ramon-Azcon
Feb 26, 2019·Journal of Applied Biomaterials & Functional Materials·Sedat OndaralOrçun Çağlar Kurtuluş
Feb 13, 2019·AAPS PharmSciTech·Mumuni SumailaViness Pillay
Jan 8, 2021·International Journal of Biological Macromolecules·Wei ShiCheng Hock Chuah
Dec 17, 2020·Pharmaceutics·Zhi Ming TanHira Choudhury
May 1, 2021·Polymers·Md Saifur RahmanMohammad Boshir Ahmed

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