Preparation and evaluation of ketoprofen hot-melt extruded enteric and sustained-release tablets

Drug Development and Industrial Pharmacy
Rui YangXuefeng Zhang

Abstract

Hot-melt extruded tablets with enteric and sustained-release properties were prepared using ketoprofen as a model drug and Eudragit L100 as the carrier. Ketoprofen, with a similar solubility parameter to Eudragit L100, was homogeneously dispersed in the polymer matrix in a non-crystalline state, and was identified by differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy analysis. To compare the enteric and sustained-release characteristics, tablets of physical mixtures and comminuted extrudates were also produced with a tensile strength of 5.0 kg/cm2. The drug release percentage was below 3% in 0.1 M HCl and a sustained release for 6 to 12 hours was obtained with the tablets prepared by direct cutting of the extrudates and by compressing the pulverized extrudates, while no enteric and sustained-release properties were exhibited by the physical mixture tablets. The release mechanisms of the two types of tablets from their extrudates were different only because of their porosity. For the cut tablets, the drug was released according to the erosion mechanism, whereas in the extruded tablets the release property was controlled by erosion and diffusion mechanisms simultaneously.

References

Aug 1, 1990·The Journal of Physiology·D G Mărgineanu, W Van Driessche
Nov 1, 1990·Journal of Pharmaceutical Sciences·S C Chi, H W Jun
Jan 7, 1999·Drug Development and Industrial Pharmacy·H J AhnC K Kim
Nov 17, 1999·Journal of Pharmaceutical Sciences·D J GreenhalghP York
May 9, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S HülsmannR Bodmeier
Feb 22, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·M A Repka, J W McGinity
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·J LiuJ W McGinity
Jan 5, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Beatrice PerissuttiFulvio Rubessa
Jun 28, 2002·International Journal of Pharmaceutics·A RodaE Roda
Aug 23, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jörg Breitenbach
Jan 16, 2003·International Journal of Pharmaceutics·Geert VerreckMarcus E Brewster
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·C De BrabanderJ P Remon
Jan 28, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·E MehuysJ P Remon
Jul 22, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michael M CrowleyJames W McGinity
Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michael A RepkaSteven P Stodghill
Jan 22, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Els MehuysChris Vervaet
Sep 2, 2005·Journal of Pharmaceutical Sciences·Suneela ProdduturiMichael A Repka
Jan 18, 2006·International Journal of Pharmaceutics·Mamoru FukudaJames W McGinity

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Citations

Oct 27, 2009·AAPS PharmSciTech·Pasquale Del GaudioRita P Aquino
Mar 23, 2011·Drug Development and Industrial Pharmacy·Fu JijunTang Xing
Jun 23, 2015·Drug Development and Industrial Pharmacy·Bart ClaeysChris Vervaet
Sep 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lorena SegaleFranco Pattarino
May 4, 2010·International Journal of Pharmaceutics·Min YangCostas Gogos
Jun 22, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Haiying WangXinggang Yang
Oct 13, 2017·Drug Development and Industrial Pharmacy·Theodoros AvgerinosIoannis Nikolakakis
Dec 2, 2008·Expert Opinion on Drug Delivery·Michael A RepkaSampada B Upadhye
Aug 16, 2021·International Journal of Pharmaceutics·Jiajie HuHonglai Liu

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