Abstract
The purpose of the present study was to develop orally disintegrating tablets (ODTs) containing fat-soluble drugs that disintegrate rapidly while having appropriate tablet strength. We chose vitamin E (VE) as a model drug; d-α-tocopheryl acetate, as the oily VE (VE-OI), and d-α-tocopheryl acid succinate, as the powder VE (VE-PO), were used. The oily VE was added directly to ODTs (VE-OI ODTs) and also used for the preparation of two types of VE granule, i.e., granules prepared using adsorption to calcium silicate (VE-FL granules) and granules prepared using spray-drying with gelatin (VE-SD granules); each type of granule was added to ODTs (VE-FL ODTs and VE-SD ODTs). Powder VE was added directly to ODTs (VE-PO ODTs). Various VE ODTs were prepared using these four additional methods with varying amounts of VE per tablet and were evaluated with respect to their manufacturability, physicochemical characteristics, and stability. It was demonstrated that a tablet porosity of 30% to 35% and tensile strength of 7 kg/cm(2) or greater are required to provide VE ODTs with rapid disintegration and appropriate tablet strength, and that VE-SD granules and powder VE are suitable forms of VE to be added. When stability tests of VE-SD ODTs and ...Continue Reading
References
Dec 1, 1991·Chemical & Pharmaceutical Bulletin·H TakeuchiH Ozawa
Feb 1, 1989·Chemical & Pharmaceutical Bulletin·T KimuraY Takeda
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Nov 1, 1994·Chemical & Pharmaceutical Bulletin·H YuasaK Shinozawa
Sep 19, 2002·Chemical & Pharmaceutical Bulletin·Yutaka MoritaKozo Takayama
Jun 16, 2004·International Journal of Pharmaceutics·G AbdelbaryPh Piccerelle
Jun 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshio KunoHiroaki Nakagami
Nov 1, 2005·International Journal of Pharmaceutics·Takao MizumotoKatsuhide Terada
Nov 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yourong FuKinam Park
Feb 8, 2006·Chemical & Pharmaceutical Bulletin·Masaaki SugimotoTetsurou Handa
Jun 6, 2006·International Journal of Pharmaceutics·Masaaki SugimotoTetsurou Handa
Jul 7, 2007·Drug Development and Industrial Pharmacy·Cristián TapiaMehrdad Yazdani-Pedram
Jan 10, 2008·International Journal of Pharmaceutics·Yoshio KunoHiroaki Nakagami
Oct 2, 2008·Chemical & Pharmaceutical Bulletin·Takuma KosekiYoshiharu Machida
Jan 20, 2010·International Journal of Pharmaceutics·Feiyan Jin, Aditya Tatavarti
Mar 25, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Farhan AlHusbanAfzal R Mohammed
Dec 9, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yayoi KawanoHiraku Onishi
Mar 23, 2011·Drug Development and Industrial Pharmacy·Yukoh Sakata, Hiroyuki Yamaguchi
Dec 6, 2011·Archives of Pharmacal Research·Ravi SheshalaYusrida Darwis
Aug 13, 2013·International Journal of Pharmaceutics·Jong-Il KimBeom-Jin Lee