Preparation and evaluation of proliposomes containing propranolol hydrochloride

Journal of Microencapsulation
B N AhnC K Shim

Abstract

Proliposomes were prepared by the penetration of a methanol-chloroform solution of propranolol hydrochloride (PH) and lecithin into microporous sorbitol, with subsequent vacuum drying. They were characterized for surface morphology and flowability, and following the conversion to liposomes upon hydration, size distribution, drug content and in vitro drug release of the reconstituted liposomes were examined. The porous structure of sorbitol was maintained in the proliposomes, affording the proliposomes good flowability at lecithin-to-sorbitol ratios (w/w) of not more than 0.2. Multilamellar liposomes were reconstituted spontaneously from the proliposomes upon hydration. The mean diameter of the resultant liposomes was highly dependent on the PH-to-lecithin ratio, but less dependent on the lecithin-to-sorbitol ratio and sorbitol particle size (105-710 microns). Entrapment efficiency of PH in liposomes showed a maximum 10% at PH-to-lecithin ratio < 0.5 and a lecithin-to-sorbitol ratio > 0.1. Sustained release of propranolol from the proliposomes was achieved when the lecithin-to-PH ratio was > 2, and the lecithin-to-sorbitol ratio was in the range examined (0.067-0.2). In conclusion, granular proliposomes of PH with good flowabili...Continue Reading

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Citations

Oct 26, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keon-Hyoung SongChang-Koo Shim
May 20, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M Ryu ShimCK
Jun 3, 2005·Chemical & Pharmaceutical Bulletin·Mei-Ying NingZhong-Wei Gu
May 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shasha RaoClive A Prestidge
Jul 9, 2008·Journal of Microencapsulation·Maha NasrA A Elshamy
Jul 27, 1999·Journal of Microencapsulation·J H Zhang, J B Zhu
Jun 30, 2006·The Journal of Pharmacy and Pharmacology·Abdelbary M A ElhissiKevin M G Taylor

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